Anti-ERVFRD-1 Antibody


Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various

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Rabbit Anti-ERVFRD-1 Antibody (CSB-PA352689ESR1HU)


Alternative names:

Syncytin-2 Antibody,Endogenous retrovirus group FRD member 1 Antibody,Envelope polyprotein Antibody,HERV-FRD Antibody,HERV-FRD_6p24.1 provirus ancestral Env polyprotein Antibody,ERVFRD-1 Antibody,ERVFRDE1 Antibody,UNQ6191/PRO20218 Antibody

More alternative names for the antibody
EFRD1_HUMAN antibody|Endogenous retrovirus group FRD member 1 antibody|Envelope polyprotein antibody|ERVFRD-1 antibody|FLJ41944 antibody|FLJ90611 antibody|GLLL6191 antibody|HERV FRD 6p24.1 provirus ancestral Env polyprotein antibody|HERV FRD antibody|HERV FRD provirus ancestral Env polyprotein antibody|HERV-FRD antibody|HERVFRD antibody|HERVFRD provirus ancestral Env polyprotein antibody|MGC87585 antibody|SU antibody|Syncytin 2 antibody|Syncytin B antibody|Syncytin-2 antibody|TM antibody|Transmembrane protein antibody|UNQ6191 antibody
Anti-HERV-FRD antibody (ab90733)
Close sc-164284|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols


Anti-ERVFRD-1 Antibody

Catalogue No.





Recombinant human Syncytin-2 protein (16-250AA)





Recommended dilution

Recommended dilution:IHC:1:20-1:200







Molecular weight

59 kDa


Antigen Affinity Purified


Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:2086( Human), Entrez Gene:30816( Human), Entrez Gene:405754( Human), Omim:610524( Human), SwissProt:O42043( Human), SwissProt:O71037( Human), SwissProt:P10267( Human), SwissProt:P60507( Human), SwissProt:P60508( Human), SwissProt:P61550( Human), SwissProt:P61565( Human), SwissProt:P61566( Human), SwissProt:P61567( Human), SwissProt:P61570( Human), SwissProt:Q14264( Human), SwissProt:Q69384( Human), SwissProt:Q902F8( Human), SwissProt:Q902F9( Human), SwissProt:Q96L62( Human), SwissProt:Q9N2J8( Human), SwissProt:Q9N2J9( Human), SwissProt:Q9N2K0( Human), SwissProt:Q9NX77( Human), SwissProt:Q9UKH3( Human), SwissProt:Q9UQF0( Human), Unigene:250693( Human), Unigene:406976( Human), Unigene:631996( Human)

Protein function

This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process (PubMed:18988732). .; Endogenous envelope proteins may have kept, lost or modified their original function during evolution but this one can still make pseudotypes with MLV, HIV-1 or SIV-1 virions and confer infectivity. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. The surface protein mediates receptor recognition, while the transmembrane protein anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (PubMed:14694139). .

Protein tissue specificity

Expressed at higher level in placenta. Expressed at lower level in adrenal, bone marrow, brain, breast, colon, kidney, lung, ovary, peripheral blood lymphocytes, prostate, skin, spleen, testis, thymus, thyroid, trachea. .

Protein sequence and domain

Belongs to the gamma type-C retroviral envelope protein family. HERV class-I FRD env subfamily. Contains the CKS-17 immunosuppressive domain present in many retroviral envelope proteins. As a synthetic peptide, it inhibits immune function in vitro and in vivo (By similarity).

Protein post-translational modifications

Specific enzymatic cleavages in vivo yield the mature SU and TM proteins. .; The CXXC motif is highly conserved across a broad range of retroviral envelope proteins. It is thought to participate in the formation of a labile disulfide bond possibly with the CX6CC motif present in the transmembrane protein. Isomerization of the intersubunit disulfide bond to an SU intrachain disulfide bond is thought to occur upon receptor recognition in order to allow membrane fusion (By similarity). .

Protein cellular localization

Virion .; Transmembrane protein: Cell membrane ; Single-pass membrane protein .

Research area

All research areas>Signaling Intermediates>ERV3
(View all antibody categories related to Signaling Intermediates)


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Product type

Primary antibody


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