Anti-ERVFRD-1 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit Anti-ERVFRD-1 Antibody (CSB-PA352689ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Syncytin-2 Antibody,Endogenous retrovirus group FRD member 1 Antibody,Envelope polyprotein Antibody,HERV-FRD Antibody,HERV-FRD_6p24.1 provirus ancestral Env polyprotein Antibody,ERVFRD-1 Antibody,ERVFRDE1 Antibody,UNQ6191/PRO20218 Antibody

More alternative names for the antibody
EFRD1_HUMAN antibody|Endogenous retrovirus group FRD member 1 antibody|Envelope polyprotein antibody|ERVFRD-1 antibody|FLJ41944 antibody|FLJ90611 antibody|GLLL6191 antibody|HERV FRD 6p24.1 provirus ancestral Env polyprotein antibody|HERV FRD antibody|HERV FRD provirus ancestral Env polyprotein antibody|HERV-FRD antibody|HERVFRD antibody|HERVFRD provirus ancestral Env polyprotein antibody|MGC87585 antibody|SU antibody|Syncytin 2 antibody|Syncytin B antibody|Syncytin-2 antibody|TM antibody|Transmembrane protein antibody|UNQ6191 antibody
Anti-HERV-FRD antibody (ab90733)
Close sc-164284|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-ERVFRD-1 Antibody

Catalogue No.

CSB-PA352689ESR1HU

Reactivity

Human

Immunogen

Recombinant human Syncytin-2 protein (16-250AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

59 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:2086( Human), Entrez Gene:30816( Human), Entrez Gene:405754( Human), Omim:610524( Human), SwissProt:O42043( Human), SwissProt:O71037( Human), SwissProt:P10267( Human), SwissProt:P60507( Human), SwissProt:P60508( Human), SwissProt:P61550( Human), SwissProt:P61565( Human), SwissProt:P61566( Human), SwissProt:P61567( Human), SwissProt:P61570( Human), SwissProt:Q14264( Human), SwissProt:Q69384( Human), SwissProt:Q902F8( Human), SwissProt:Q902F9( Human), SwissProt:Q96L62( Human), SwissProt:Q9N2J8( Human), SwissProt:Q9N2J9( Human), SwissProt:Q9N2K0( Human), SwissProt:Q9NX77( Human), SwissProt:Q9UKH3( Human), SwissProt:Q9UQF0( Human), Unigene:250693( Human), Unigene:406976( Human), Unigene:631996( Human)

Protein function

This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process (PubMed:18988732). .; Endogenous envelope proteins may have kept, lost or modified their original function during evolution but this one can still make pseudotypes with MLV, HIV-1 or SIV-1 virions and confer infectivity. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. The surface protein mediates receptor recognition, while the transmembrane protein anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (PubMed:14694139). .

Protein tissue specificity

Expressed at higher level in placenta. Expressed at lower level in adrenal, bone marrow, brain, breast, colon, kidney, lung, ovary, peripheral blood lymphocytes, prostate, skin, spleen, testis, thymus, thyroid, trachea. .

Protein sequence and domain

Belongs to the gamma type-C retroviral envelope protein family. HERV class-I FRD env subfamily. Contains the CKS-17 immunosuppressive domain present in many retroviral envelope proteins. As a synthetic peptide, it inhibits immune function in vitro and in vivo (By similarity).

Protein post-translational modifications

Specific enzymatic cleavages in vivo yield the mature SU and TM proteins. .; The CXXC motif is highly conserved across a broad range of retroviral envelope proteins. It is thought to participate in the formation of a labile disulfide bond possibly with the CX6CC motif present in the transmembrane protein. Isomerization of the intersubunit disulfide bond to an SU intrachain disulfide bond is thought to occur upon receptor recognition in order to allow membrane fusion (By similarity). .

Protein cellular localization

Virion .; Transmembrane protein: Cell membrane ; Single-pass membrane protein .

Research area

All research areas>Signaling Intermediates>ERV3
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!