Anti-ESRRA Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-ESRRA Antibody (CSB-PA007834DSR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Estrogen receptor-like 1 Antibody,Estrogen-related receptor alpha Antibody,ERR-alpha Antibody,Nuclear receptor subfamily 3 group B member 1 Antibody,ESRRA Antibody,ERR1 Antibody, ESRL1 Antibody,NR3B1 Antibody

More alternative names for the antibody
Err 1 antibody|Estrra antibody|hERR1 antibody|NR3B1 antibody|Nuclear receptor subfamily 3 group B member 1 antibody|Steroid hormone receptor ERR1 antibody
Anti-Estrogen Related Receptor alpha antibody [EPR46Y] (ab76228)
Close sc-65715|sc-65718|sc-65722|sc-65720|sc-32972|sc-66882|sc-32971|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-ESRRA Antibody

Catalogue No.

CSB-PA007834DSR2HU

Reactivity

Human

Immunogen

Recombinant human Steroid hormone receptor ERR1 protein (1-423AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

45 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:2101( Human), Entrez Gene:26379( Mouse), Entrez Gene:293701( Rat), Omim:601998( Human), SwissProt:P11474( Human), SwissProt:O08580( Mouse), SwissProt:Q5QJV7( Rat), Unigene:110849( Human), Unigene:386776( Mouse), Unigene:130171( Rat)

Protein function

Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5′-TNAAGGTCA-3′. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle. .

Protein sequence and domain

Belongs to the nuclear hormone receptor family. NR3 subfamily.

Protein post-translational modifications

Phosphorylation on Ser-19 enhances sumoylation on Lys-14 increasing repression of transcriptional activity. .; Sumoylated with SUMO2. Main site is Lys-14 which is enhanced by phosphorylation on Ser-19, cofactor activation, and by interaction with PIAS4. Sumoylation enhances repression of transcriptional activity, but has no effect on subcellular location nor on DNA binding. .; Reversibly acetylated. Acetylation by PCAF/KAT2 at Lys-129, Lys-138, Lys-160 and Lys-162 and PCAF/KAT2 decreases transcriptional activity probably by inhibiting DNA-binding activity; deacetylation involves SIRT1 and HDAC8 and increases DNA-binding. .

Protein cellular localization

Nucleus .

Research area

All research areas>Steroid Receptors>Estrogen Related Receptor
(View all antibody categories related to Steroid Receptors)

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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