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Rabbit Anti-ETV6 Antibody (CSB-PA007860ESR1HU)
Supplier: CUSABIO BIOTECH CO.
ETS translocation variant 6 Antibody,ETS-related protein Tel1 Antibody,Tel Antibody,ETV6 Antibody,TEL Antibody, TEL1 AntibodyMore alternative names for the antibody
ETV 6 antibody|ETV6 antibody|ETV6_HUMAN antibody|Tel antibody|TEL oncogene antibody|TEL/ABL antibody|TEL1 antibody|TEL1 oncogene antibody|Transcription factor ETV 6 antibody|Transcription factor ETV6 antibody
Anti-ETV6 / Tel antibody (ab185816)
Anti-ETV6 / Tel antibody (ab185816)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Transcription factor ETV6 protein (1-300AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:2120( Human), Entrez Gene:14011( Mouse), Entrez Gene:312777( Rat), Omim:600618( Human), SwissProt:P41212( Human), SwissProt:P97360( Mouse), Unigene:504765( Human), Unigene:269995( Mouse), Unigene:147424( Rat)
|Protein function|| |
Transcriptional repressor; binds to the DNA sequence 5′-CCGGAAGT-3′. Plays a role in hematopoiesis and malignant transformation. .
|Protein tissue specificity|| |
|Involvement in disease|| |
Note=A chromosomal aberration involving ETV6 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;12)(q33;p13) with PDGFRB. It is characterized by abnormal clonal myeloid proliferation and by progression to acute myelogenous leukemia (AML). .; Note=Chromosomal aberrations involving ETV6 are found in acute myeloid leukemia (AML). Translocation t(12;22)(p13;q11) with MN1 (PubMed:7731705). Translocation t(4;12)(q12;p13) with CHIC2 (PubMed:10477709). .; Note=Chromosomal aberrations involving ETV6 are found in childhood acute lymphoblastic leukemia (ALL). Translocations t(12;21)(p12;q22) and t(12;21)(p13;q22) with RUNX1/AML1. .; Note=A chromosomal aberration involving ETV6 is found in a form of pre-B acute lymphoid leukemia. Translocation t(9;12)(p24;p13) with JAK2. .; Note=A chromosomal aberration involving ETV6 and JAK2 is found in an atypical chronic myelogenous leukemia. Translocation t(9;15;12)(p24;q15;p13). .; Note=A chromosomal aberration involving ETV6 is found in myelodysplastic syndrome (MDS) with basophilia. Translocation t(5;12)(q31;p13) with ACSL6. .; Note=A chromosomal aberration involving ETV6 is found in acute eosinophilic leukemia (AEL). Translocation t(5;12)(q31;p13) with ACSL6. .; Note=A chromosomal aberration involving ETV6 is found in myelodysplastic syndrome (MDS). Translocation t(1;12)(p36.1;p13) with MDS2. .; Note=A chromosomal aberration involving ETV6 is found in acute lymphoblastic leukemia. Translocation t(9;12)(p13;p13) with PAX5. .; Myeloproliferative disorder chronic with eosinophilia (MPE) [MIM:131440]: A hematologic disorder characterized by malignant eosinophils proliferation. . Note=The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving ETV6 is found in many instances of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;12) with PDGFRB on chromosome 5 creating an ETV6-PDGFRB fusion protein. .; Leukemia, acute myelogenous (AML) [MIM:601626]: A subtype of acute leukemia, a cancer of the white blood cells. AML is a malignant disease of bone marrow characterized by maturational arrest of hematopoietic precursors at an early stage of development. Clonal expansion of myeloid blasts occurs in bone marrow, blood, and other tissue. Myelogenous leukemias develop from changes in cells that normally produce neutrophils, basophils, eosinophils and monocytes. . Note=The gene represented in this entry is involved in disease pathogenesis.; Thrombocytopenia 5 (THC5) [MIM:616216]: Thrombocytopenia is defined by a decrease in the number of platelets in circulating blood, resulting in the potential for increased bleeding and decreased ability for clotting. THC5 is an autosomal dominant disorder, associated with an increased susceptibility to the development of hematologic and solid malignancies. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the ETS family.
|Protein post-translational modifications|| |
Phosphorylation of Ser-257 by MAPK14 (p38) inhibits ETV6 transcriptional repression. .
|Protein cellular localization|| |
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