Anti-EYA3 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit Anti-EYA3 Antibody (CSB-PA860766DSR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Eyes absent homolog 3 Antibody,EYA3 Antibody

More alternative names for the antibody
AI844637 antibody|DKFZp686C132 antibody|EYA3 antibody|EYA3_HUMAN antibody|Eyes absent 3 antibody|Eyes absent 3 homolog (Drosophila) antibody|Eyes absent homolog 3 antibody|OTTMUSP00000010370 antibody|RP11-460I13.4 antibody|RP23-442A20.1 antibody
Anti-EYA3 antibody (ab22835)
Close sc-15101|

Recommended applications: ELISA, WB, IHC

Recommended dilution: User optimized

Recommended protocols: check protocols

Name

Anti-EYA3 Antibody

Catalogue No.

CSB-PA860766DSR2HU

Reactivity

Human

Immunogen

Recombinant human Eyes absent homolog 3 protein (1-300AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

User optimized

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

62 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:2140( Human), Entrez Gene:14050( Mouse), Entrez Gene:313027( Rat), Omim:601655( Human), SwissProt:Q99504( Human), SwissProt:P97480( Mouse), Unigene:185774( Human), Unigene:227733( Mouse)

Protein function

Tyrosine phosphatase that specifically dephosphorylates ‘Tyr-142’ of histone H2AX (H2AXY142ph). ‘Tyr-142’ phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 (PubMed:19234442, PubMed:19351884). Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity (By similarity). May be involved in development of the eye. .

Protein sequence and domain

Belongs to the HAD-like hydrolase superfamily. EYA family.

Protein post-translational modifications

Ser-266 phosphorylation is required for localization at sites of DNA damage and directing interaction with H2AX. .

Protein cellular localization

Cytoplasm . Nucleus . Note=Localizes at sites of DNA damage at double-strand breaks (DSBs) (PubMed:19234442). With decreasing efficiency, translocalized to the nucleus by SIX2 and SIX5, and SIX4, respectively (By similarity). .

Research area

All research areas>Neurobiology Antibodies>EYA
(View all antibody categories related to Neurobiology Antibodies)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!