No products in the cart.
Rabbit Anti-EYA3 Antibody (CSB-PA860766DSR1HU)
Supplier: CUSABIO BIOTECH CO.
Eyes absent homolog 3 Antibody,EYA3 AntibodyMore alternative names for the antibody
AI844637 antibody|DKFZp686C132 antibody|EYA3 antibody|EYA3_HUMAN antibody|Eyes absent 3 antibody|Eyes absent 3 homolog (Drosophila) antibody|Eyes absent homolog 3 antibody|OTTMUSP00000010370 antibody|RP11-460I13.4 antibody|RP23-442A20.1 antibody
Anti-EYA3 antibody (ab22835)
Anti-EYA3 antibody (ab22835)
Recommended applications: ELISA, WB, IHC
Recommended dilution: User optimized
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Eyes absent homolog 3 protein (1-300AA)
ELISA, WB, IHC
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2140" target="_blank">Entrez Gene:2140( Human)</a>, <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=14050" target="_blank">Entrez Gene:14050( Mouse)</a>, <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=313027" target="_blank">Entrez Gene:313027( Rat)</a>, <a href="http://www.ncbi.nlm.nih.gov/omim/601655" target="_blank">Omim:601655( Human)</a>, <a href="http://www.uniprot.org/uniprot/Q99504" target="_blank">SwissProt:Q99504( Human)</a>, <a href="http://www.uniprot.org/uniprot/P97480" target="_blank">SwissProt:P97480( Mouse)</a>, <a href="http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=185774" target="_blank">Unigene:185774( Human)</a>, <a href="http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Mm&CID=227733" target="_blank">Unigene:227733( Mouse)</a>
|Protein function|| |
Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 (PubMed:19234442, PubMed:19351884). Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity (By similarity). May be involved in development of the eye. .
|Protein sequence and domain|| |
Belongs to the HAD-like hydrolase superfamily. EYA family.
|Protein post-translational modifications|| |
Ser-266 phosphorylation is required for localization at sites of DNA damage and directing interaction with H2AX. .
|Protein cellular localization|| |
Cytoplasm . Nucleus . Note=Localizes at sites of DNA damage at double-strand breaks (DSBs) (PubMed:19234442). With decreasing efficiency, translocalized to the nucleus by SIX2 and SIX5, and SIX4, respectively (By similarity). .
|Research area|| |
<a href="https://antibodyplus.com/research-areas/">All research areas</a>><a href="https://antibodyplus.com/Neurobiology-Antibodies/">Neurobiology Antibodies</a>><a href="https://antibodyplus.com/product-tag/EYA/">EYA</a><br><a href="https://antibodyplus.com/product-tag/Neurobiology-Antibodies/"> (View all antibody categories related to Neurobiology Antibodies)</a>
AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.
CUSABIO BIOTECH CO.
|Product type|| |
There are no reviews for this product yet.
By submitting a review, get following benefits:
1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!
There is no extra validation for this product yet.
Check other extra validated antibodies below: