Anti-FADD Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-FADD Antibody (CSB-PA623788ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

FAS-associating death domain-containing protein Antibody,Growth-inhibiting gene 3 protein Antibody,Mediator of receptor induced toxicity Antibody,Protein FADD Antibody,FADD Antibody,MORT1 Antibody,GIG3 Antibody

More alternative names for the antibody
FADD antibody|FADD protein antibody|FADD_HUMAN antibody|Fas (TNFRSF6) associated via death domain antibody|Fas associated via death domain antibody|Fas associating death domain containing protein antibody|Fas associating protein antibody|Fas associating protein with death domain antibody|Fas TNFRSF6 associated via death domain antibody|FAS-associated death domain protein antibody|FAS-associating death domain-containing protein antibody|GIG 3 antibody|GIG3 antibody|Growth inhibiting gene 3 protein antibody|Growth-inhibiting gene 3 protein antibody|H sapiens mRNA for mediator of receptor induced toxicity antibody|Mediator of receptor induced toxicity antibody|MGC8528 antibody|MORT 1 antibody|MORT1 antibody|Protein FADD antibody
Anti-FADD antibody (ab24533)
Close sc-271748|sc-134337|sc-292676|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-FADD Antibody

Catalogue No.

CSB-PA623788ESR1HU

Reactivity

Human

Immunogen

Recombinant human FAS-associated death domain protein (1-208AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

23 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:8772( Human), Entrez Gene:14082( Mouse), Entrez Gene:266610( Rat), Omim:602457( Human), SwissProt:Q13158( Human), SwissProt:Q61160( Mouse), Unigene:86131( Human), Unigene:5126( Mouse), Unigene:16183( Rat)

Protein function

Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. .

Protein tissue specificity

Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes.

Involvement in disease

Infections, recurrent, associated with encephalopathy, hepatic dysfunction and cardiovascular malformations (IEHDCM) [MIM:613759]: A condition with biological features of autoimmune lymphoproliferative syndrome such as high-circulating CD4(-)CD8(-)TCR-alpha-beta(+) T-cell counts, and elevated IL10 and FASL levels. Affected individuals suffer from recurrent, stereotypical episodes of fever, encephalopathy, and mild liver dysfunction sometimes accompanied by generalized seizures. The episodes can be triggered by varicella zoster virus (VZV), measles mumps rubella (MMR) attenuated vaccine, parainfluenza virus, and Epstein-Barr virus (EBV). . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Contains a death domain involved in the binding of the corresponding domain within Fas receptor.; The interaction between the FAS and FADD death domains is crucial for the formation of the death-inducing signaling complex (DISC).

Research area

All research areas>Tumor Suppressor/Apoptosis>FADD
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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