Anti-FBXL5 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-FBXL5 Antibody (CSB-PA892451ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

F-box/LRR-repeat protein 5 Antibody,F-box and leucine-rich repeat protein 5 Antibody,F-box protein FBL4/FBL5 Antibody,p45SKP2-like protein Antibody,FBXL5 Antibody,FBL4 Antibody,FBL5 Antibody,FLR1 Antibody

More alternative names for the antibody
F box and leucine rich repeat protein 5 antibody|F box protein FBL5 antibody|F box/LRR repeat protein 5 antibody|F-box and leucine-rich repeat protein 5 antibody|F-box protein FBL4/FBL5 antibody|F-box/LRR-repeat protein 5 antibody|FBL4 antibody|FBL5 antibody|FBXL5 antibody|FBXL5_HUMAN antibody|FLR1 antibody|p45SKP2 like protein antibody|p45SKP2-like protein antibody
Anti-FBXL5 antibody (ab140175)
Close sc-390102|sc-134984|sc-54364|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-FBXL5 Antibody

Catalogue No.

CSB-PA892451ESR1HU

Reactivity

Human

Immunogen

Recombinant human F-box/LRR-repeat protein 5 protein (1-310AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

78 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:26234( Human), Entrez Gene:242960( Mouse), Entrez Gene:305424( Rat), Omim:605655( Human), SwissProt:Q9UKA1( Human), SwissProt:Q8C2S5( Mouse), Unigene:643433( Human), Unigene:714386( Human), Unigene:25794( Mouse)

Protein function

Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued. .

Protein sequence and domain

The hemerythrin-like region acts as an oxygen and iron sensor by binding oxygen through a diiron metal-center. In absence of oxygen and iron, the protein is ubiquitinated and degraded.

Protein post-translational modifications

Polybiquitinated upon iron and oxygen depletion, leading to its degradation by the proteasome. Ubiquitination is regulated by the hemerythrin-like region that acts as an oxygen and iron sensor. .

Protein cellular localization

Cytoplasm, perinuclear region .

Research area

All research areas>Signaling Intermediates>FBL
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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