Anti-FBXO7 Antibody

$99.00$319.00

Reactivity: Human,Mouse
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-FBXO7 Antibody (CSB-PA667562ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

F-box only protein 7 Antibody,FBXO7 Antibody,FBX7 Antibody

More alternative names for the antibody
F box only protein 7 antibody|F box protein 7 antibody|F-box only protein 7 antibody|FBX antibody|FBX07 antibody|FBX7 antibody|FBX7_HUMAN antibody|Fbxo7 antibody|PARK15 antibody|PKPS antibody
Anti-FBXO7 antibody (ab84129)
Close sc-271763|sc-86448|sc-86450|

Recommended applications: ELISA, WB, IHC

Recommended dilution: User optimized

Recommended protocols: check protocols

Name

Anti-FBXO7 Antibody

Catalogue No.

CSB-PA667562ESR2HU

Reactivity

Human, Mouse

Immunogen

Recombinant human F-box only protein 7 protein (353-522AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

User optimized

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

58 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:25793( Human), Entrez Gene:69754( Mouse), Entrez Gene:366854( Rat), Omim:605648( Human), SwissProt:Q9Y3I1( Human), SwissProt:Q3U7U3( Mouse), SwissProt:Q68FS3( Rat), Unigene:5912( Human), Unigene:44236( Mouse), Unigene:20218( Rat)

Protein function

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PARK2 to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination. .

Involvement in disease

Parkinson disease 15 (PARK15) [MIM:260300]: A neurodegenerative disorder characterized by parkinsonian and pyramidal signs. Clinical manifestations include tremor, bradykinesia, rigidity, postural instability, spasticity, mainly in the lower limbs, and hyperreflexia. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

The ubiquitin-like region mediates interaction with PARK2.; The proline-rich region is important for protein-protein interactions.

Protein cellular localization

Cytoplasm. Nucleus. Mitochondrion. Cytoplasm, cytosol. Note=Predominantly cytoplasmic. A minor proportion is detected in the nucleus. Relocates from the cytosol to depolarized mitochondria.

Research area

All research areas>Signaling Intermediates>FBXO
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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