Anti-FBXW11 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-FBXW11 Antibody (CSB-PA891721ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

F-box and WD repeats protein beta-TrCP2 Antibody,F-box/WD repeat-containing protein 1B Antibody,Homologous to Slimb protein Antibody, HOS Antibody,FBXW11 Antibody,BTRCP2 Antibody, FBW1B Antibody, FBXW1B Antibody, KIAA0696 Antibody

More alternative names for the antibody
beta Transducin Repeat Containing Protein 2 antibody|BTRC2 antibody|BTRCP2 antibody|F-box and WD repeats protein beta-TrCP2 antibody|F-box and WD-40 Domain Protein 1B antibody|F-box Protein FBW1B antibody|F-box/WD repeat-containing protein 11 antibody|F-box/WD repeat-containing protein 1B antibody|FBW1B antibody|FBW1B_HUMAN antibody|FBXW11 antibody|FBXW1B antibody|Homologous to Slimb protein antibody|HOS antibody
Anti-beta TRCP2 antibody (ab154070)
Close sc-166492|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-FBXW11 Antibody

Catalogue No.

CSB-PA891721ESR2HU

Reactivity

Human

Immunogen

Recombinant human F-box/WD repeat-containing protein 11 protein (1-140AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

62 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:23291( Human), Entrez Gene:103583( Mouse), Omim:605651( Human), SwissProt:Q9UKB1( Human), SwissProt:Q5SRY7( Mouse), Unigene:484138( Human), Unigene:28017( Mouse)

Protein function

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. SCF(FBXW11) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (PubMed:25503564). Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. Is target of human immunodeficiency virus type 1 (HIV-1) protein VPU to polyubiquitinate and deplete BST2 from cells and antagonize its antiviral action. .

Protein sequence and domain

The N-terminal D domain mediates homodimerization.

Protein cellular localization

Cytoplasm . Nucleus .

Research area

All research areas>Synthesis and Degradation>β-TrCP
(View all antibody categories related to Synthesis and Degradation)

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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