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Rabbit Anti-FKBP4 Antibody (CSB-PA008700ESR1HU)
Supplier: CUSABIO BIOTECH CO.
PPIase FKBP4 Antibody,51 kDa FK506-binding protein Antibody, FKBP51 Antibody,52 kDa FK506-binding protein Antibody,52 kDa FKBP Antibody,FKBP-52 Antibody,59 kDa immunophilin Antibody,p59 Antibody,FK506-binding protein 4 Antibody, FKBP-4 Antibody,FKBP59 Antibody,HSP-binding immunophilin Antibody,HBI Antibody,Immunophilin FKBP52 Antibody,Rotamase Antibody,FKBP4 Antibody,FKBP52 AntibodyMore alternative names for the antibody
51 kDa FK506-binding protein antibody|52 kDa FK506 binding protein antibody|52 kDa FK506-binding protein antibody|52 kDa FKBP antibody|59 kDa immunophilin antibody|FK506 binding protein 4 antibody|FK506-binding protein 4 antibody|FKBP 4 antibody|FKBP 52 antibody|FKBP 59 antibody|FKBP-4 antibody|FKBP-52 antibody|FKBP4 antibody|FKBP4_HUMAN antibody|FKBP51 antibody|FKBP52 protein antibody|FKBP59 antibody|HBI antibody|Hsp 56 antibody|HSP binding immunophilin antibody|HSP-binding immunophilin antibody|Hsp56 antibody|Immunophilin FKBP52 antibody|N-terminally processed antibody|p52 antibody|p59 antibody|p59 protein antibody|Peptidyl prolyl cis trans isomerase antibody|Peptidyl-prolyl cis-trans isomerase FKBP4 antibody|Peptidylprolyl cis trans isomerase antibody|PPIase antibody|PPIase FKBP4 antibody|Rotamase antibody|T cell FK506 binding protein 59kD antibody
Anti-FKBP52 antibody [EPR6618] (ab129097)
Anti-FKBP52 antibody [EPR6618] (ab129097)
Recommended applications: ELISA, WB, IHC, IP
Recommended dilution: Recommended dilution:WB:1:1000-1:5000,IHC:1:20-1:200,IP:1:200-1:2000
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Peptidyl-prolyl cis-trans isomerase FKBP4 protein (220-459AA)
ELISA, WB, IHC, IP
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:2288( Human), Entrez Gene:14228( Mouse), Entrez Gene:260321( Rat), Omim:600611( Human), SwissProt:Q02790( Human), SwissProt:P30416( Mouse), SwissProt:Q9QVC8( Rat), Unigene:524183( Human), Unigene:713721( Human), Unigene:12758( Mouse), Unigene:23741( Rat)
|Protein function|| |
Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. .
|Protein tissue specificity|| |
Widely expressed. .
|Protein sequence and domain|| |
The PPIase activity is mainly due to the fisrt PPIase FKBP-type domain (1-138 AA).; The C-terminal region (AA 375-458) is required to prevent tubulin polymerization.; The chaperone activity resides in the C-terminal region, mainly between amino acids 264 and 400.; The TPR repeats mediate mitochondrial localization.
|Protein post-translational modifications|| |
Phosphorylation by CK2 results in loss of HSP90 binding activity. .
|Protein cellular localization|| |
Cytoplasm, cytosol . Mitochondrion . Nucleus . Cytoplasm, cytoskeleton . Cell projection, axon . Note=Shuttles from mitochondria to nucleus; co-localizes in mitochondria with the glucocorticoid receptor (PubMed:21730050). Colocalized with MAPT/TAU in the distal part of the primary cortical neurons (By similarity). .
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CUSABIO BIOTECH CO.
|Product type|| |
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