Anti-FZD3 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-FZD3 Antibody (CSB-PA882067ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Frizzled-3 Antibody,Fz-3 Antibody,hFz3 Antibody,FZD3 Antibody

More alternative names for the antibody
Frizzled 3 antibody|Frizzled 3 seven transmembrane spanning receptor antibody|Frizzled family receptor 3 antibody|Frizzled homolog 3 (Drosophila) antibody|Frizzled homolog 3 antibody|Frizzled-3 antibody|Frizzled3 antibody|Fz 3 antibody|Fz-3 antibody|Fz3 antibody|FZD 3 antibody|Fzd3 antibody|FZD3_HUMAN antibody|hFz 3 antibody|hFz3 antibody
Anti-FZD3 antibody (ab217032)
Close sc-376105|sc-68333|sc-68334|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-FZD3 Antibody

Catalogue No.

CSB-PA882067ESR2HU

Reactivity

Human

Immunogen

Recombinant human Frizzled-3 protein (23-205AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

76 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:7976( Human), Entrez Gene:14365( Mouse), Entrez Gene:266715( Rat), Omim:606143( Human), SwissProt:Q9NPG1( Human), SwissProt:Q61086( Mouse), Unigene:40735( Human), Unigene:214687( Mouse), Unigene:404299( Mouse), Unigene:178695( Rat)

Protein function

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in controlling early axon growth and guidance processes necessary for the formation of a subset of central and peripheral major fiber tracts. Required for the development of major fiber tracts in the central nervous system, including: the anterior commissure, the corpus callosum, the thalamocortical, corticothalamic and nigrostriatal tracts, the corticospinal tract, the fasciculus retroflexus, the mammillothalamic tract, the medial lemniscus, and ascending fiber tracts from the spinal cord to the brain. In the peripheral nervous system, controls axon growth in distinct populations of cranial and spinal motor neurons, including the facial branchimotor nerve, the hypoglossal nerve, the phrenic nerve, and motor nerves innervating dorsal limbs. Involved in the migration of cranial neural crest cells. May also be implicated in the transmission of sensory information from the trunk and limbs to the brain. Controls commissural sensory axons guidance after midline crossing along the anterior-posterior axis in the developing spinal cord in a Wnt-dependent signaling pathway. Together with FZD6, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear. Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle in a beta-catenin-dependent manner (By similarity). .

Protein tissue specificity

Widely expressed. Relatively high expression in the CNS, including regions of the limbic system, in kidney, pancreas, skeletal muscle, uterus and testis.

Protein sequence and domain

Belongs to the G-protein coupled receptor Fz/Smo family. Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.; The FZ domain is involved in binding with Wnt ligands.

Protein post-translational modifications

Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. .

Protein cellular localization

Membrane; Multi-pass membrane protein. Cell membrane ; Multi-pass membrane protein . Cell surface . Apical cell membrane ; Multi-pass membrane protein. Note=Colocalizes with FZD6 at the apical face of the cell (By similarity). .

Research area

All research areas>Membrane Receptors>frizzled
(View all antibody categories related to Membrane Receptors)

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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