Anti-G3BP1 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-G3BP1 Antibody (CSB-PA613389ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

G3BP-1 Antibody,ATP-dependent DNA helicase VIII Antibody,hDH VIII Antibody,GAP SH3 domain-binding protein 1 Antibody,G3BP1 Antibody,G3BP Antibody

More alternative names for the antibody
ATP dependent DNA helicase VIII antibody|ATP-dependent DNA helicase VIII antibody|G3BP antibody|G3BP-1 antibody|G3bp1 antibody|G3BP1_HUMAN antibody|GAP binding protein antibody|GAP SH3 domain binding protein 1 antibody|GAP SH3 domain-binding protein 1 antibody|GTPase activating protein (SH3 domain) binding protein 1 antibody|hDH VIII antibody|Human DNA helicase VIII antibody|MGC111040 antibody|Ras GTPase activating protein binding protein 1 antibody|Ras GTPase activating protein SH3 domain binding protein antibody|Ras GTPase-activating protein-binding protein 1 antibody|RasGAP associated endoribonuclease G3BP antibody
Anti-G3BP antibody (ab56574)
Close sc-70283|sc-365338|sc-98561|sc-70286|sc-81940|sc-161612|

Recommended applications: ELISA, WB, IHC

Recommended dilution: Recommended dilution:WB:1:500-2000,IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-G3BP1 Antibody

Catalogue No.

CSB-PA613389ESR1HU

Reactivity

Human

Immunogen

Recombinant human Ras GTPase-activating protein-binding protein 1 protein (227-466AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

Recommended dilution:WB:1:500-2000,IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

52 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:10146( Human), Omim:608431( Human), SwissProt:Q13283( Human), Unigene:587054( Human)

Protein function

May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3′-UTR. ATP- and magnesium-dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3′ tail or hanging tails at both 5′- and 3′-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5′ to 3′ direction along the bound single-stranded DNA. .

Protein tissue specificity

Ubiquitous.

Protein sequence and domain

The NTF2 domain mediates multimerization.

Protein post-translational modifications

Phosphorylated exclusively on serine residues. Hyperphosphorylated in quiescent fibroblasts. Hypophosphorylation leads to a decrease in endoribonuclease activity (By similarity). RASA1-dependent phosphorylation of Ser-149 induces a conformational change that prevents self-association. Dephosphorylation after HRAS activation is required for stress granule assembly. Ser-149 phosphorylation induces partial nuclear localization. .; Arg-435 is dimethylated, probably to asymmetric dimethylarginine.

Protein cellular localization

Cytoplasm. Cytoplasm, cytosol. Cytoplasmic granule. Cell membrane. Nucleus. Note=Cytoplasmic in proliferating cells, can be recruited to the plasma membrane in exponentially growing cells (By similarity). Cytosolic and partially nuclear in resting cells. Recruited to stress granules (SGs) upon either arsenite or high temperature treatment. Recruitment to SGs is influenced by HRAS. .

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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