Anti-GABARAPL1 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-GABARAPL1 Antibody (CSB-PA861986DSR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Gamma-aminobutyric acid receptor-associated protein-like 1 Antibody,Early estrogen-regulated protein Antibody,GABA(A) receptor-associated protein-like 1 Antibody,Glandular epithelial cell protein 1 Antibody,GEC-1 Antibody,GABARAPL1 Antibody,GEC1 Antibody

More alternative names for the antibody
Early estrogen-regulated protein antibody|GABA(A) receptor-associated protein-like 1 antibody|GABA(A) receptor-associated protein-like 3 antibody|Gamma-aminobutyric acid receptor-associated protein-like 1 antibody|Gamma-aminobutyric acid receptor-associated protein-like 3 antibody|GEC-1 antibody|Glandular epithelial cell protein 1 antibody
Anti-GABARAPL1 + GABARAPL3 antibody [EPR18869] (ab191887)
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Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-GABARAPL1 Antibody

Catalogue No.

CSB-PA861986DSR2HU

Reactivity

Human

Immunogen

Recombinant human Gamma-aminobutyric acid receptor-associated protein-like 1 protein (1-117AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

14 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:23710( Human), Entrez Gene:23766( Human), Entrez Gene:57436( Mouse), Entrez Gene:689161( Rat), Omim:607420( Human), SwissProt:Q9BY60( Human), SwissProt:Q9H0R8( Human), SwissProt:Q8R3R8( Mouse), SwissProt:Q0VGK0( Rat), Unigene:524250( Human), Unigene:592014( Human), Unigene:14638( Mouse), Unigene:118264( Rat)

Protein function

Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. .

Protein tissue specificity

Ubiquitous. Expressed at very high levels in the brain, heart, peripheral blood leukocytes, liver, kidney, placenta and skeletal muscle. Expressed at very low levels in thymus and small intestine. In the brain, expression is particularly intense in motoneurons in the embryo and in neurons involved in somatomotor and neuroendocrine functions in the adult, particularly in the substantia nigra pars compacta. .

Protein sequence and domain

Belongs to the ATG8 family.

Protein post-translational modifications

The precursor molecule is cleaved by ATG4B to form the cytosolic form, GABARAPL1-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, GABARAPL1-II (By similarity). ATG4B also mediates the delipidation required for GABARAPL1 recycling when autophagosomes fuse with lysosomes (PubMed:20404487). .; The Legionella effector RavZ is a deconjugating enzyme that produces an ATG8 product that would be resistant to reconjugation by the host machinery due to the cleavage of the reactive C-terminal glycine. .

Protein cellular localization

Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Lipid-anchor. Endoplasmic reticulum . Golgi apparatus . Cytoplasmic vesicle, autophagosome.

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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