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Rabbit Anti-GALNT3 Antibody (CSB-PA613501ESR1HU)
Supplier: CUSABIO BIOTECH CO.
Polypeptide N-acetylgalactosaminyltransferase 3 Antibody,Polypeptide GalNAc transferase 3 Antibody,GalNAc-T3 Antibody,pp-GaNTase 3 Antibody,Protein-UDP acetylgalactosaminyltransferase 3 Antibody,UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3 Antibody,GALNT3 AntibodyMore alternative names for the antibody
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Polypeptide N-acetylgalactosaminyltransferase 3 protein (1-140AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Protein function|| |
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward HIV envelope glycoprotein gp120, EA2, Muc2 and Muc5. Probably glycosylates fibronectin in vivo. Glycosylates FGF23. Plays a central role in phosphate homeostasis. .
|Protein tissue specificity|| |
Expressed in organs that contain secretory epithelial glands. Highly expressed in pancreas, skin, kidney and testis. Weakly expressed in prostate, ovary, intestine and colon. Also expressed in placenta and lung and fetal lung and fetal kidney. .
|Involvement in disease|| |
Tumoral calcinosis, hyperphosphatemic, familial (HFTC) [MIM:211900]: A severe metabolic disorder that manifests with hyperphosphatemia and massive calcium deposits in the skin and subcutaneous tissues. Some patients manifest recurrent, transient, painful swellings of the long bones associated with the radiographic findings of periosteal reaction and cortical hyperostosis and absence of skin involvement. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily. There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.; The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
|Protein cellular localization|| |
Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein . Note=Resides preferentially in the trans and medial parts of the Golgi stack.
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CUSABIO BIOTECH CO.
|Product type|| |
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