Anti-GALNT3 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-GALNT3 Antibody (CSB-PA613501ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Polypeptide N-acetylgalactosaminyltransferase 3 Antibody,Polypeptide GalNAc transferase 3 Antibody,GalNAc-T3 Antibody,pp-GaNTase 3 Antibody,Protein-UDP acetylgalactosaminyltransferase 3 Antibody,UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3 Antibody,GALNT3 Antibody

More alternative names for the antibody

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Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-GALNT3 Antibody

Catalogue No.

CSB-PA613501ESR1HU

Reactivity

Human

Immunogen

Recombinant human Polypeptide N-acetylgalactosaminyltransferase 3 protein (1-140AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

72 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Protein function

Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward HIV envelope glycoprotein gp120, EA2, Muc2 and Muc5. Probably glycosylates fibronectin in vivo. Glycosylates FGF23. Plays a central role in phosphate homeostasis. .

Protein tissue specificity

Expressed in organs that contain secretory epithelial glands. Highly expressed in pancreas, skin, kidney and testis. Weakly expressed in prostate, ovary, intestine and colon. Also expressed in placenta and lung and fetal lung and fetal kidney. .

Involvement in disease

Tumoral calcinosis, hyperphosphatemic, familial (HFTC) [MIM:211900]: A severe metabolic disorder that manifests with hyperphosphatemia and massive calcium deposits in the skin and subcutaneous tissues. Some patients manifest recurrent, transient, painful swellings of the long bones associated with the radiographic findings of periosteal reaction and cortical hyperostosis and absence of skin involvement. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily. There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.; The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.

Protein cellular localization

Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein . Note=Resides preferentially in the trans and medial parts of the Golgi stack.

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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