Anti-GOPC Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-GOPC Antibody (CSB-PA862075ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

CFTR-associated ligand Antibody,Fused in glioblastoma Antibody,PDZ protein interacting specifically with TC10 Antibody, PIST Antibody,GOPC Antibody,CAL Antibody, FIG Antibody

More alternative names for the antibody
CAL antibody|CFTR associated ligand antibody|CFTR-associated ligand antibody|dJ94G16.2 antibody|dJ94G16.2 PIST antibody|FIG antibody|Fused in glioblastoma antibody|Golgi associated PDZ and coiled coil motif containing antibody|Golgi associated PDZ and coiled coil motif containing protein antibody|Golgi-associated PDZ and coiled-coil motif-containing protein antibody|GOPC 1 antibody|GOPC antibody|GOPC_HUMAN antibody|GOPC1 antibody|OTTHUMP00000040403 antibody|PDZ protein interacting specifically with TC 10 antibody|PDZ protein interacting specifically with TC10 antibody|PDZ/coiled coil domain binding partner for the rho family GTPase TC 10 antibody|PDZ/coiled coil domain binding partner for the rho family GTPase TC10 antibody|PIST antibody|Protein interacting specifically with Tc 10 antibody|Protein interacting specifically with Tc10 antibody
Anti-PIST antibody [EPR4079] (ab109119)
Close sc-393026|sc-74836|

Recommended applications: ELISA, WB, IHC

Recommended dilution: Recommended dilution:WB:1:500-5000,IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-GOPC Antibody

Catalogue No.

CSB-PA862075ESR1HU

Reactivity

Human

Immunogen

Recombinant human Golgi-associated PDZ and coiled-coil motif-containing protein (203-462AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

Recommended dilution:WB:1:500-5000,IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

50 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:57120( Human), Entrez Gene:94221( Mouse), Omim:606845( Human), SwissProt:Q9HD26( Human), SwissProt:Q3TAF1( Mouse), SwissProt:Q8BH60( Mouse), Unigene:191539( Human), Unigene:390258( Mouse)

Protein function

Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes. .

Protein tissue specificity

Ubiquitously expressed. .

Involvement in disease

Note=A chromosomal aberration involving GOPC is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity. .

Protein sequence and domain

The PDZ domain mediates interactions with FZD5, FZD8, ASIC3, GRID2, CLCN3 (By similarity). Mediates also interaction with CFTR and ADRB1.; The coiled-coil region probably mediates association to membranes, targeting to the Golgi, and interactions with GOLGA3, and STX6. May also mediate interaction with RHOQ (By similarity).

Protein cellular localization

Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Cell junction, synapse . Cell junction, synapse, postsynaptic cell membrane, postsynaptic density . Cell projection, dendrite . Note=Enriched in synaptosomal and postsynaptic densities (PSD) fractions. Expressed in cell bodies and dendrites of Purkinje cells. Localized at the trans-Golgi network (TGN) of spermatids and the medulla of round spermatides. .

Research area

All research areas>Transport and Trafficking>PIST
(View all antibody categories related to Transport and Trafficking)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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