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Rabbit Anti-GPR126 Antibody (CSB-PA768200ESR2HU)
Supplier: CUSABIO BIOTECH CO.
G-protein coupled receptor 126 Antibody,Developmentally regulated G-protein-coupled receptor Antibody,Vascular inducible G protein-coupled receptor Antibody,GPR126 Antibody,DREG Antibody,VIGR AntibodyMore alternative names for the antibody
APG1 antibody|Developmentally regulated G-protein-coupled receptor antibody|dj287g14.2 antibody|DREG antibody|G-protein coupled receptor 126 antibody|GP126_HUMAN antibody|GPR126 antibody|HBV PreS1-transactivated protein 2 antibody|OTTHUMP00000017320 antibody|OTTHUMP00000237093 antibody|OTTHUMP00000237094 antibody|OTTHUMP00000237115 antibody|Probable G-protein coupled receptor 126 [Precursor] antibody|Probable G-protein coupled receptor 126 antibody|PS1TP2 antibody|Vascular inducible G protein-coupled receptor antibody|VIGR antibody
Anti-GPCR GPR126 antibody (ab150562)
Anti-GPCR GPR126 antibody (ab150562)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human G-protein coupled receptor 126 protein (40-300AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:534326( Cow), Entrez Gene:101132799( Gorilla), Entrez Gene:57211( Human), Entrez Gene:100404865( Marmoset (common)), Entrez Gene:215798( Mouse), Entrez Gene:100352263( Rabbit), Entrez Gene:308376( Rat), Omim:612243( Human), SwissProt:Q86SQ4( Human), SwissProt:Q6F3F9( Mouse), Unigene:318894( Human), Unigene:726094( Human), Unigene:440142( Mouse)
|Protein function|| |
G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane (By similarity). Couples to G(i)-proteins as well as G(s)-proteins (PubMed:24227709). Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons (PubMed:24227709). Regulates neural, cardiac and ear development via G-protein- and/or N-terminus-dependent signaling (By similarity). May act as a receptor for PRNP which may promote myelin homeostasis (By similarity). .
|Protein tissue specificity|| |
Expressed in placenta and to a lower extent in pancreas and liver. Detected in aortic endothelial cells but not in skin microvascular endothelial cells. .
|Involvement in disease|| |
Lethal congenital contracture syndrome 9 (LCCS9) [MIM:616503]: A form of lethal congenital contracture syndrome, an autosomal recessive disorder characterized by degeneration of anterior horn neurons, extreme skeletal muscle atrophy and congenital non-progressive joint contractures. The contractures can involve the upper or lower limbs and/or the vertebral column, leading to various degrees of flexion or extension limitations evident at birth. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. A short peptide sequence (termed the Stachel sequence) in the C-terminal part of the extra-cellular domain (ECD) functions as a tethered agonist. Upon structural changes within the ECD, e.g. due to extracellular ligand binding or mechanical movements, this intramolecular agonist is exposed to the 7TM domain, triggering G-protein activation.
|Protein post-translational modifications|| |
Proteolytically cleaved into 2 conserved sites: one in the GPS domain (S1 site) and the other in the middle of the extracellular domain (S2 site). The proteolytic cleavage at S1 site generates an extracellular subunit and a seven-transmembrane subunit. Furin is involved in the cleavage of the S2 site generating a soluble fragment. Processing at the GPS domain occurred independent of and probably prior to the cleavage at the S2 site. Proteolytic cleavage is required for activation of the receptor. .; Highly glycosylated. .
|Protein cellular localization|| |
Cell membrane ; Multi-pass membrane protein . Note=Detected on the cell surface of activated but not resting umbilical vein. .
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CUSABIO BIOTECH CO.
|Product type|| |
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