Anti-GPR126 Antibody

$99.00$319.00

Reactivity: Human,Mouse
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-GPR126 Antibody (CSB-PA768200ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

G-protein coupled receptor 126 Antibody,Developmentally regulated G-protein-coupled receptor Antibody,Vascular inducible G protein-coupled receptor Antibody,GPR126 Antibody,DREG Antibody,VIGR Antibody

More alternative names for the antibody
APG1 antibody|Developmentally regulated G-protein-coupled receptor antibody|dj287g14.2 antibody|DREG antibody|G-protein coupled receptor 126 antibody|GP126_HUMAN antibody|GPR126 antibody|HBV PreS1-transactivated protein 2 antibody|OTTHUMP00000017320 antibody|OTTHUMP00000237093 antibody|OTTHUMP00000237094 antibody|OTTHUMP00000237115 antibody|Probable G-protein coupled receptor 126 [Precursor] antibody|Probable G-protein coupled receptor 126 antibody|PS1TP2 antibody|Vascular inducible G protein-coupled receptor antibody|VIGR antibody
Anti-GPCR GPR126 antibody (ab150562)
Close sc-292188|sc-107579|

Recommended applications: ELISA, WB, IHC

Recommended dilution: User optimized

Recommended protocols: check protocols

Name

Anti-GPR126 Antibody

Catalogue No.

CSB-PA768200ESR1HU

Reactivity

Human, Mouse

Immunogen

Recombinant human G-protein coupled receptor 126 protein (40-300AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

User optimized

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

136 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:534326( Cow), Entrez Gene:101132799( Gorilla), Entrez Gene:57211( Human), Entrez Gene:100404865( Marmoset (common)), Entrez Gene:215798( Mouse), Entrez Gene:100352263( Rabbit), Entrez Gene:308376( Rat), Omim:612243( Human), SwissProt:Q86SQ4( Human), SwissProt:Q6F3F9( Mouse), Unigene:318894( Human), Unigene:726094( Human), Unigene:440142( Mouse)

Protein function

G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane (By similarity). Couples to G(i)-proteins as well as G(s)-proteins (PubMed:24227709). Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons (PubMed:24227709). Regulates neural, cardiac and ear development via G-protein- and/or N-terminus-dependent signaling (By similarity). May act as a receptor for PRNP which may promote myelin homeostasis (By similarity). .

Protein tissue specificity

Expressed in placenta and to a lower extent in pancreas and liver. Detected in aortic endothelial cells but not in skin microvascular endothelial cells. .

Involvement in disease

Lethal congenital contracture syndrome 9 (LCCS9) [MIM:616503]: A form of lethal congenital contracture syndrome, an autosomal recessive disorder characterized by degeneration of anterior horn neurons, extreme skeletal muscle atrophy and congenital non-progressive joint contractures. The contractures can involve the upper or lower limbs and/or the vertebral column, leading to various degrees of flexion or extension limitations evident at birth. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. A short peptide sequence (termed the Stachel sequence) in the C-terminal part of the extra-cellular domain (ECD) functions as a tethered agonist. Upon structural changes within the ECD, e.g. due to extracellular ligand binding or mechanical movements, this intramolecular agonist is exposed to the 7TM domain, triggering G-protein activation.

Protein post-translational modifications

Proteolytically cleaved into 2 conserved sites: one in the GPS domain (S1 site) and the other in the middle of the extracellular domain (S2 site). The proteolytic cleavage at S1 site generates an extracellular subunit and a seven-transmembrane subunit. Furin is involved in the cleavage of the S2 site generating a soluble fragment. Processing at the GPS domain occurred independent of and probably prior to the cleavage at the S2 site. Proteolytic cleavage is required for activation of the receptor. .; Highly glycosylated. .

Protein cellular localization

Cell membrane ; Multi-pass membrane protein . Note=Detected on the cell surface of activated but not resting umbilical vein. .

Research area

All research areas>Membrane Receptors>GPR
(View all antibody categories related to Membrane Receptors)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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