Anti-GPRC5A Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-GPRC5A Antibody (CSB-PA818781DSR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

G-protein coupled receptor family C group 5 member A Antibody,Orphan G-protein-coupling receptor PEIG-1 Antibody,Retinoic acid-induced gene 1 protein Antibody,RAIG-1 Antibody,GPRC5A Antibody,GPCR5A Antibody, RAI3 Antibody, RAIG1 Antibody

More alternative names for the antibody
G protein coupled receptor family C group 5 member A antibody|G-protein coupled receptor family C group 5 member A antibody|GPCR 5A antibody|GPCR5A antibody|Gprc 5a antibody|Gprc5a antibody|Orphan G protein coupling receptor PEIG 1 antibody|Orphan G protein coupling receptor PEIG1 antibody|Orphan G-protein-coupling receptor PEIG-1 antibody|RAI 3 antibody|RAI3_HUMAN antibody|Raig 1 antibody|RAIG-1 antibody|Raig1 antibody|Retinoic acid induced 3 antibody|Retinoic acid induced gene 1 protein antibody|Retinoic acid induced protein 3 antibody|Retinoic acid responsive antibody|Retinoic acid responsive gene antibody|Retinoic acid-induced gene 1 protein antibody|Retinoic acid-induced protein 3 antibody
Anti-RAI3 antibody – Extracellular domain (ab188905)
Close sc-390263|sc-373824|sc-373825|sc-98884|

Recommended applications: ELISA, WB, IHC

Recommended dilution: Recommended dilution:WB:1:500-5000,IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-GPRC5A Antibody

Catalogue No.

CSB-PA818781DSR1HU

Reactivity

Human

Immunogen

Recombinant human Retinoic acid-induced protein 3 protein (258-357AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

Recommended dilution:WB:1:500-5000,IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

40 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:516026( Cow), Entrez Gene:486680( Dog), Entrez Gene:101151750( Gorilla), Entrez Gene:101822388( Hamster), Entrez Gene:9052( Human), Entrez Gene:232431( Mouse), Entrez Gene:312790( Rat), Omim:604138( Human), SwissProt:Q8NFJ5( Human), SwissProt:Q8BHL4( Mouse), Unigene:631733( Human), Unigene:23575( Mouse), Unigene:477015( Mouse)

Protein function

Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling (By similarity). May act as a lung tumor suppressor (PubMed:18000218). .

Protein tissue specificity

Expressed at high level in fetal and adult lung tissues but repressed in most human lung cancers (PubMed:9857033, PubMed:18000218). Constitutively expressed in fetal kidney and adult placenta, kidney, prostate, testis, ovary, small intestine, colon, stomach, and spinal chord at low to moderate levels. Not detectable in fetal heart, brain, and liver and adult heart, brain, liver, skeletal muscle, pancreas, spleen, thymus, and peripheral leukocytes. According to PubMed:10783259, expressed at low but detectable level in pancreas and heart. .

Protein sequence and domain

Belongs to the G-protein coupled receptor 3 family.

Protein post-translational modifications

Phosphorylated in two conserved double-tyrosine motifs, TYR-317/TYR-320 and TYR-347/TYR-350, by EGFR; leading to inactivation of the tumor suppressive function of GPRC5A in lung cancer cells. TYR-317 and TYR-320 are the preferred residues responsible for EGFR-mediated GPRC5A phosphorylation. .

Protein cellular localization

Cell membrane ; Multi-pass membrane protein . Cytoplasmic vesicle membrane ; Multi-pass membrane protein . Note=Localized in perinuclear vesicles, probably Golgi-associated vesicles. .

Research area

All research areas>Neurobiology Antibodies>RAI
(View all antibody categories related to Neurobiology Antibodies)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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