Anti-GPS1 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-GPS1 Antibody (CSB-PA615663ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

SGN1 Antibody,Signalosome subunit 1 Antibody,G protein pathway suppressor 1 Antibody,GPS-1 Antibody,JAB1-containing signalosome subunit 1 Antibody,Protein MFH Antibody,GPS1 Antibody,COPS1 Antibody,CSN1 Antibody

More alternative names for the antibody
COP9 signalosome complex subunit 1 antibody|COP9 signalosome subunit 1 antibody|COPS1 antibody|CSN 1 antibody|CSN1_HUMAN antibody|FUS6/COP11, Arabidopsis, homolog of antibody|G protein pathway suppressor 1 antibody|GPS-1 antibody|Gps1 antibody|JAB1-containing signalosome subunit 1 antibody|Protein GPS1 antibody|Protein MFH antibody|SGN1 antibody|Signalosome subunit 1 antibody
Anti-CSN1 antibody [EP15642-22] (ab194359)
Close sc-365617|sc-514086|sc-377134|sc-292637|sc-47854|sc-47856|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-GPS1 Antibody

Catalogue No.

CSB-PA615663ESR2HU

Reactivity

Human

Immunogen

Recombinant human COP9 signalosome complex subunit 1 protein (222-491AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

55 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:2873( Human), Entrez Gene:209318( Mouse), Entrez Gene:117039( Rat), Omim:601934( Human), SwissProt:Q13098( Human), SwissProt:Q99LD4( Mouse), SwissProt:P97834( Rat), Unigene:268530( Human), Unigene:30195( Mouse), Unigene:16873( Rat)

Protein function

Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction. .

Protein tissue specificity

Widely expressed. .

Protein sequence and domain

Belongs to the CSN1 family. The PCI domain is necessary and sufficient for the interactions with other CSN subunits of the complex. Mediates the interaction with CAPN8 (By similarity).; The N-terminal part (1-216), which is not required for deneddylating activity and CSN complex formation, is nevertheless essential for other aspects of CSN complex function, such as repression of c-fos/FOS expression.

Protein cellular localization

Cytoplasm . Nucleus .

Research area

All research areas>Signaling Intermediates>CSN
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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