Anti-GRB7 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-GRB7 Antibody (CSB-PA009890ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

B47 Antibody,Epidermal growth factor receptor GRB-7 Antibody,GRB7 adapter protein Antibody,GRB7 Antibody

More alternative names for the antibody
B47 antibody|Epidermal growth factor receptor GRB 7 antibody|Epidermal growth factor receptor GRB-7 antibody|GRB7 adapter protein antibody|GRB7 antibody|GRB7_HUMAN antibody|Growth factor receptor bound protein 7 antibody|Growth factor receptor-bound protein 7 antibody|OTTHUMP00000164349 antibody|OTTHUMP00000164350 antibody|OTTHUMP00000164351 antibody|OTTHUMP00000164352 antibody
Anti-GRB7 antibody [EPR4378] (ab109618)
Close sc-376069|sc-373982|sc-606|sc-13954|sc-607|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-GRB7 Antibody

Catalogue No.

CSB-PA009890ESR2HU

Reactivity

Human

Immunogen

Recombinant human Growth factor receptor-bound protein 7 protein (233-532AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

59 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:2886( Human), Entrez Gene:14786( Mouse), Entrez Gene:84427( Rat), Omim:601522( Human), SwissProt:Q14451( Human), SwissProt:Q03160( Mouse), SwissProt:Q9QZC5( Rat), Unigene:86859( Human), Unigene:276702( Mouse)

Protein function

Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5’UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity). .

Protein sequence and domain

Belongs to the GRB7/10/14 family. The PH domain mediates interaction with membranes containing phosphoinositides.

Protein post-translational modifications

Phosphorylated on serine and threonine residues in response to heregulin. Phosphorylated on tyrosine residues by TEK/TIE2. Phosphorylated on tyrosine residues in response to NTN1 signaling. Phosphorylation promotes stress granule disassembly during recovery after cellular stress (By similarity). Phosphorylated on tyrosine residues by PTK2/FAK1, and possibly also other kinases. Phosphorylation is enhanced by activation of receptor kinases. Tyrosine phosphorylation is essential for activation of down-stream protein kinases. .

Protein cellular localization

Cytoplasm . Cell junction, focal adhesion . Cell membrane; Peripheral membrane protein; Cytoplasmic side . Cytoplasmic granule . Cell projection . Note=Predominantly cytoplasmic. Detected in stress granules, where mRNA is stored under stress conditions. .

Research area

All research areas>Signaling Intermediates>GRB
(View all antibody categories related to Signaling Intermediates)

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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