Anti-GRIN2B Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-GRIN2B Antibody (CSB-PA615671DSR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

GluN2B Antibody,Glutamate [NMDA] receptor subunit epsilon-2 Antibody,N-methyl D-aspartate receptor subtype 2B Antibody,NMDAR2B Antibody,NR2B Antibody,N-methyl-D-aspartate receptor subunit 3 Antibody,NR3 Antibody,hNR3 Antibody,GRIN2B Antibody,NMDAR2B Antibody

More alternative names for the antibody
GRIN2B antibody|Glutamate [NMDA] receptor subunit epsilon 1 antibody|Glutamate [NMDA] receptor subunit epsilon 2 antibody|Glutamate [NMDA] receptor subunit epsilon-1 antibody|Glutamate [NMDA] receptor subunit epsilon-2 antibody|GRIN2A antibody|hNR2A antibody|hNR3 antibody|N methyl D aspartate receptor subtype 2A antibody|N methyl D aspartate receptor subtype 2B antibody|N-methyl D-aspartate receptor subtype 2A antibody|N-methyl D-aspartate receptor subtype 2B antibody|N-methyl-D-aspartate receptor subunit 3 antibody|NMDAR2A antibody|NMDAR2B antibody|NMDE1_HUMAN antibody|NR2A antibody|NR2B antibody|NR3 antibody
Phospho anti-NMDAR2A + 2B (Y1246 + Y1252) antibody (ab62436)
Close sc-365597|sc-1469|sc-31545|sc-9057|sc-31543|sc-1470|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-GRIN2B Antibody

Catalogue No.

CSB-PA615671DSR2HU

Reactivity

Human

Immunogen

Recombinant human Glutamate receptor ionotropic, NMDA 2B protein (1185-1484AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

166 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:2903( Human), Entrez Gene:2904( Human), Entrez Gene:14811( Mouse), Entrez Gene:14812( Mouse), Entrez Gene:24409( Rat), Entrez Gene:24410( Rat), Omim:138252( Human), Omim:138253( Human), SwissProt:Q12879( Human), SwissProt:Q13224( Human), SwissProt:P35436( Mouse), SwissProt:Q01097( Mouse), SwissProt:Q00959( Rat), SwissProt:Q00960( Rat), Unigene:411472( Human), Unigene:654430( Human), Unigene:2953( Mouse), Unigene:9710( Rat)

Protein function

NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity). .

Protein tissue specificity

Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia. .

Involvement in disease

Mental retardation, autosomal dominant 6 (MRD6) [MIM:613970]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Epileptic encephalopathy, early infantile, 27 (EIEE27) [MIM:616139]: A form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Note=A chromosomal aberrations involving GRIN2B has been found in patients with mental retardation. Translocations t(9;12)(p23;p13.1) and t(10;12)(q21.1;p13.1) with a common breakpoint in 12p13.1.

Protein sequence and domain

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2B/GRIN2B subfamily.

Protein post-translational modifications

Phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity. .

Protein cellular localization

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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