Anti-H2AFY Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-H2AFY Antibody (CSB-PA010098DSR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Core histone macro-H2A.1 Antibody,Histone macroH2A1 Antibody,mH2A1 Antibody,Histone H2A.y Antibody,H2A/y Antibody,Medulloblastoma antigen MU-MB-50.205 Antibody,H2AFY Antibody,MACROH2A1 Antibody

More alternative names for the antibody
Core histone macro h2a.1 antibody|Core histone macro-H2A.1 antibody|H2A histone family member Y antibody|H2A.y antibody|H2A/y antibody|H2AF12M antibody|H2AFJ antibody|H2afy antibody|H2AY_HUMAN antibody|Histone H2A.Y antibody|Histone macroH2A1 antibody|Histone macroH2A1.1 antibody|Histone macroH2A1.2 antibody|Macroh2a1 antibody|MACROH2A1.1 antibody|MacroH2A1.2 antibody|Medulloblastoma antigen MU MB 50.205 antibody|Medulloblastoma antigen MU-MB-50.205 antibody|mH2a antibody|mH2A1 antibody
Anti-macroH2A.1 antibody – ChIP Grade (ab37264)
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Recommended applications: ELISA, WB, IHC

Recommended dilution: User optimized

Recommended protocols: check protocols

Name

Anti-H2AFY Antibody

Catalogue No.

CSB-PA010098DSR1HU

Reactivity

Human

Immunogen

Recombinant human Core histone macro-H2A.1 protein (123-372AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

User optimized

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

39 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:9555( Human), Entrez Gene:26914( Mouse), Entrez Gene:29384( Rat), Omim:610054( Human), SwissProt:O75367( Human), SwissProt:Q9QZQ8( Mouse), SwissProt:Q02874( Rat), Unigene:420272( Human), Unigene:599225( Human), Unigene:283802( Mouse), Unigene:478369( Mouse), Unigene:11098( Rat)

Protein function

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription (PubMed:12718888, PubMed:15621527, PubMed:16428466). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation (PubMed:15897469). Inhibits the binding of transcription factors, including NF-kappa-B, and interferes with the activity of remodeling SWI/SNF complexes (PubMed:12718888, PubMed:16428466). Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces a hypoacetylated state of chromatin (PubMed:16428466, PubMed:16107708). .; Isoform 1: Binds ADP-ribose and O-acetyl-ADP-ribose, and may be involved in ADP-ribose-mediated chromatin modulation (PubMed:15902274). Increases the expression of genes involved in redox metabolism, including SOD3 (PubMed:23022728). .; Isoform 2: Represses SOD3 gene expression. .

Protein tissue specificity

Widely expressed. .

Protein post-translational modifications

Monoubiquitinated at either Lys-116 or Lys-117. May also be polyubiquitinated. Ubiquitination is mediated by the CUL3/SPOP E3 complex and does not promote proteasomal degradation. Instead, it is required for enrichment in inactive X chromosome chromatin. .

Protein cellular localization

Nucleus . Chromosome . Note=Enriched in inactive X chromosome chromatin and in senescence-associated heterochromatin. .

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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