Anti-HDAC6 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-HDAC6 Antibody (CSB-PA010242ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

HD6 Antibody,HDAC6 Antibody,KIAA0901 Antibody,JM21 Antibody

More alternative names for the antibody
CPBHM antibody|FLJ16239 antibody|HD 6 antibody|HD6 antibody|HDAC 6 antibody|HDAC6 antibody|HDAC6_HUMAN antibody|Histone deacetylase 6 (HD6) antibody|Histone deacetylase 6 antibody|JM 21 antibody|JM21 antibody|KIAA0901 antibody|OTTHUMP00000032398 antibody|OTTHUMP00000197663 antibody|PPP1R90 antibody|Protein phosphatase 1 regulatory subunit 90 antibody
Anti-HDAC6 antibody (ab1440)
Close sc-28386|sc-11420|sc-5258|sc-5255|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-HDAC6 Antibody

Catalogue No.

CSB-PA010242ESR1HU

Reactivity

Human

Immunogen

Recombinant human Histone deacetylase 6 protein (160-470AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

131 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:10013( Human), Entrez Gene:15185( Mouse), Entrez Gene:84581( Rat), Omim:300272( Human), SwissProt:Q9UBN7( Human), SwissProt:Q9Z2V5( Mouse), Unigene:6764( Human), Unigene:29854( Mouse)

Protein function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. .; In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy.

Involvement in disease

Chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia (CDP-PBHM) [MIM:300863]: A disease characterized by chondrodysplasia, severe platyspondyly, hydrocephaly, and facial features with microphthalmia. Bone abnormalities include a distinctive metaphyseal cupping of the metacarpals, metatarsals, and phalanges. Affected females show a milder phenotype with small stature, sometimes associated with body asymmetry and mild mental retardation. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the histone deacetylase family. HD type 2 subfamily.

Protein post-translational modifications

Phosphorylated by AURKA. .; Ubiquitinated. Its polyubiquitination however does not lead to its degradation. .; Sumoylated in vitro. .

Protein cellular localization

Nucleus. Cytoplasm. Perikaryon . Cell projection, dendrite . Cell projection, axon . Note=It is mainly cytoplasmic, where it is associated with microtubules.

Research area

All research areas>Transcription Regulators>HDAC
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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