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Rabbit Anti-HDAC6 Antibody (CSB-PA010242ESR1HU)
Supplier: CUSABIO BIOTECH CO.
HD6 Antibody,HDAC6 Antibody,KIAA0901 Antibody,JM21 AntibodyMore alternative names for the antibody
CPBHM antibody|FLJ16239 antibody|HD 6 antibody|HD6 antibody|HDAC 6 antibody|HDAC6 antibody|HDAC6_HUMAN antibody|Histone deacetylase 6 (HD6) antibody|Histone deacetylase 6 antibody|JM 21 antibody|JM21 antibody|KIAA0901 antibody|OTTHUMP00000032398 antibody|OTTHUMP00000197663 antibody|PPP1R90 antibody|Protein phosphatase 1 regulatory subunit 90 antibody
Anti-HDAC6 antibody (ab1440)
Anti-HDAC6 antibody (ab1440)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Histone deacetylase 6 protein (160-470AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Protein function|| |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. .; In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy.
|Involvement in disease|| |
Chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia (CDP-PBHM) [MIM:300863]: A disease characterized by chondrodysplasia, severe platyspondyly, hydrocephaly, and facial features with microphthalmia. Bone abnormalities include a distinctive metaphyseal cupping of the metacarpals, metatarsals, and phalanges. Affected females show a milder phenotype with small stature, sometimes associated with body asymmetry and mild mental retardation. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the histone deacetylase family. HD type 2 subfamily.
|Protein post-translational modifications|| |
Phosphorylated by AURKA. .; Ubiquitinated. Its polyubiquitination however does not lead to its degradation. .; Sumoylated in vitro. .
|Protein cellular localization|| |
Nucleus. Cytoplasm. Perikaryon . Cell projection, dendrite . Cell projection, axon . Note=It is mainly cytoplasmic, where it is associated with microtubules.
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CUSABIO BIOTECH CO.
|Product type|| |
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