Anti-HDAC8 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-HDAC8 Antibody (CSB-PA010244ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

HD8 Antibody,HDACL1 Antibody,HDAC8 Antibody,CDA07 Antibody

More alternative names for the antibody
CDA07 antibody|CDLS5 antibody|HD 8 antibody|HD8 antibody|HDAC 8 antibody|Hdac8 antibody|HDAC8_HUMAN antibody|HDACL 1 antibody|HDACL1 antibody|Histone deacetylase 8 antibody|Histone deacetylase like 1 antibody|MRXS6 antibody|RPD 3 antibody|RPD3 antibody|WTS antibody
Anti-HDAC8 antibody [EPR10338(2)] (ab187139)
Close sc-365620|sc-17778|sc-374180|sc-11405|sc-56687|sc-11544|sc-398003|

Recommended applications: ELISA, WB, IHC

Recommended dilution: Recommended dilution:WB:1:200-1000,IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-HDAC8 Antibody

Catalogue No.

CSB-PA010244ESR2HU

Reactivity

Human

Immunogen

Recombinant human Histone deacetylase 8 protein (1-377AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

Recommended dilution:WB:1:200-1000,IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

41 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:55869( Human), Entrez Gene:70315( Mouse), Entrez Gene:363481( Rat), Omim:300269( Human), SwissProt:Q9BY41( Human), SwissProt:Q8VH37( Mouse), SwissProt:B1WC68( Rat), Unigene:310536( Human), Unigene:328128( Mouse), Unigene:208476( Rat)

Protein function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility. .

Protein tissue specificity

Weakly expressed in most tissues. Expressed at higher level in heart, brain, kidney and pancreas and also in liver, lung, placenta, prostate and kidney. .

Involvement in disease

Cornelia de Lange syndrome 5 (CDLS5) [MIM:300882]: A form of Cornelia de Lange syndrome, a clinically heterogeneous developmental disorder associated with malformations affecting multiple systems. It is characterized by facial dysmorphisms, abnormal hands and feet, growth delay, cognitive retardation, hirsutism, gastroesophageal dysfunction and cardiac, ophthalmologic and genitourinary anomalies. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Wilson-Turner X-linked mental retardation syndrome (WTS) [MIM:309585]: A neurologic disorder characterized by severe intellectual disability, dysmorphic facial features, hypogonadism, short stature, and truncal obesity. Affected females have a milder phenotype than affected males. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the histone deacetylase family. HD type 1 subfamily.

Protein post-translational modifications

Phosphorylated by PKA on serine 39. Phosphorylation reduces deacetylase activity observed preferentially on histones H3 and H4. .

Protein cellular localization

Nucleus. Cytoplasm. Note=Excluded from the nucleoli. Found in the cytoplasm of cells showing smooth muscle differentiation.

Research area

All research areas>Transcription Regulators>HDAC
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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