Anti-HIP1 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-HIP1 Antibody (CSB-PA010365ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

HIP-1 Antibody,Huntingtin-interacting protein I Antibody,HIP-I Antibody

More alternative names for the antibody
2610109B09Rik antibody|A930014B11Rik antibody|E130315I21Rik antibody|HIP 1 antibody|HIP I antibody|HIP-1 antibody|HIP-I antibody|hip1 antibody|HIP1/PDGFRB fusion gene antibody|HIP1/PDGFRB fusion gene, included antibody|HIP1_HUMAN antibody|HIPI antibody|Huntingtin interacting protein 1 antibody|Huntingtin-interacting protein 1 antibody|Huntingtin-interacting protein I antibody|ILWEQ antibody|KIAA4113 antibody|MGC126506 antibody|MGC27616 antibody|mKIAA4113 antibody
Anti-Huntingtin Interacting Protein HIP1 antibody [EPR10814] (ab181238)
Close sc-136415|sc-47755|sc-135936|sc-47754|sc-271341|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-HIP1 Antibody

Catalogue No.

CSB-PA010365ESR1HU

Reactivity

Human

Immunogen

Recombinant human Huntingtin-interacting protein 1 protein (410-690AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

116 kDa

Purification

Antigen Affinity purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:3092( Human), Entrez Gene:215114( Mouse), Entrez Gene:192154( Rat), Omim:601767( Human), SwissProt:O00291( Human), SwissProt:Q8VD75( Mouse), Unigene:329266( Human), Unigene:619089( Human), Unigene:280805( Mouse), Unigene:836( Rat)

Protein function

Plays a role in clathrin-mediated endocytosis and trafficking (PubMed:11532990, PubMed:11577110, PubMed:11889126). Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner (By similarity). Regulates presynaptic nerve terminal activity (By similarity). Enhances androgen receptor (AR)-mediated transcription (PubMed:16027218). May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway (PubMed:11007801). Binds 3-phosphoinositides (via ENTH domain) (PubMed:14732715). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis (PubMed:14732715). May play a functional role in the cell filament networks (PubMed:18790740). May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors (PubMed:11007801, PubMed:12163454). .

Protein tissue specificity

Ubiquitously expressed with the highest level in brain. Expression is up-regulated in prostate and colon cancer. .

Involvement in disease

Note=A chromosomal aberration involving HIP1 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;7)(q33;q11.2) with PDGFRB (PubMed:9616134). The chimeric HIP1-PDGFRB transcript results from an in-frame fusion of the two genes (PubMed:9616134). The reciprocal PDGFRB-HIP1 transcript is not expressed (PubMed:9616134). .

Protein sequence and domain

Belongs to the SLA2 family. The pseudo DED region (pDED) mediates the interaction with IFT57.; Binds F-actin via the talin-like I/LWEQ domain.

Protein cellular localization

Cytoplasm. Nucleus. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Note=Shuttles between cytoplasm and nucleus. Nuclear translocation can be induced by AR.

Research area

All research areas>Neurobiology Antibodies>Huntingtin-Interacting Protein
(View all antibody categories related to Neurobiology Antibodies)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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