Anti-HNRNPD Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-HNRNPD Antibody (CSB-PA618874DSR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

hnRNP D0 Antibody,AU-rich element RNA-binding protein 1 Antibody,HNRNPD Antibody,AUF1 Antibody, HNRPD Antibody

More alternative names for the antibody
ARE binding protein AUFI type A antibody|AU-rich element RNA-binding protein 1 antibody|AUF antibody|AUF1 antibody|AUF1A antibody|Heterogeneous nuclear ribonucleoprotein D0 antibody|hnRNP D antibody|hnRNP D0 antibody|Hnrnpd antibody|hnRNPD0 antibody|HNRPD antibody|HNRPD_HUMAN antibody|P37 antibody
Anti-hnRNP D/AUF1 antibody (ab61193)
Close sc-22369|sc-22368|sc-137249|sc-16504|sc-393076|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-HNRNPD Antibody

Catalogue No.

CSB-PA618874DSR2HU

Reactivity

Human

Immunogen

Recombinant human Heterogeneous nuclear ribonucleoprotein D0 protein (1-306AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

38 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:3184( Human), Entrez Gene:11991( Mouse), Entrez Gene:79256( Rat), GenBank:NP_112738.1( Human), Omim:601324( Human), SwissProt:Q14103( Human), SwissProt:Q60668( Mouse), SwissProt:Q9JJ54( Rat), Unigene:480073( Human), Unigene:150231( Mouse), Unigene:94022( Rat)

Protein function

Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3′-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5′-UUAG-3′ sequence and also weaker to the single-stranded 5′-TTAGGG-3′ telomeric DNA repeat. Binds RNA oligonucleotides with 5′-UUAGGG-3′ repeats more tightly than the telomeric single-stranded DNA 5′-TTAGGG-3′ repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3’UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation. .

Protein post-translational modifications

Arg-345 is dimethylated, probably to asymmetric dimethylarginine.; Methylated by PRMT1, in an insulin-dependent manner. The PRMT1-mediated methylation regulates tyrosine phosphorylation (By similarity). .

Protein cellular localization

Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Component of ribonucleosomes. Cytoplasmic localization oscillates diurnally.

Research area

All research areas>Transcription Regulators>hnRNP
(View all antibody categories related to Transcription Regulators)

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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