Anti-HSPA2 Antibody

$99.00$319.00

Reactivity: Human,Rat
Applications: ELISA,WB,IHC,IP
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-HSPA2 Antibody (CSB-PA010824ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Heat shock 70 kDa protein 2 Antibody,HSPA2 Antibody

More alternative names for the antibody
70kDa antibody|
Anti-HSPA2 antibody [EPR4596] (ab108416)
Close sc-160010|

Recommended applications: ELISA, WB, IHC, IP

Recommended dilution: Recommended dilution:WB:1:1000-1:5000,IHC:1:20-1:200,IP:1:200-1:2000

Recommended protocols: check protocols

Name

Anti-HSPA2 Antibody

Catalogue No.

CSB-PA010824ESR2HU

Reactivity

Human, Rat

Immunogen

Recombinant human Heat shock-related 70 kDa protein 2 protein (400-639AA)

Host

Rabbit

Applications

ELISA, WB, IHC, IP

Recommended dilution

Recommended dilution:WB:1:1000-1:5000,IHC:1:20-1:200,IP:1:200-1:2000

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

70 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:3306( Human), Entrez Gene:15512( Mouse), Entrez Gene:60460( Rat), Omim:140560( Human), SwissProt:P54652( Human), SwissProt:P17156( Mouse), SwissProt:P14659( Rat), Unigene:728938( Human), Unigene:296181( Mouse), Unigene:211303( Rat)

Protein function

Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Plays a role in spermatogenesis. In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells (By similarity). .

Protein sequence and domain

Belongs to the heat shock protein 70 family. The N-terminal nucleotide binding domain (NBD) (also known as the ATPase domain) is responsible for binding and hydrolyzing ATP. The C-terminal substrate-binding domain (SBD) (also known as peptide-binding domain) binds to the client/substrate proteins. The two domains are allosterically coupled so that, when ATP is bound to the NBD, the SBD binds relatively weakly to clients. When ADP is bound in the NBD, a conformational change enhances the affinity of the SBD for client proteins.

Protein cellular localization

Cytoplasm, cytoskeleton, spindle . Note=Colocalizes with SHCBP1L at spindle during the meiosis process. .

Research area

All research areas>Signaling Intermediates>HSPA
(View all antibody categories related to Signaling Intermediates)

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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