Anti-HTRA2 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-HTRA2 Antibody (CSB-PA010902ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

High temperature requirement protein A2 Antibody,HtrA2 Antibody,Omi stress-regulated endoprotease Antibody,Serine protease 25 Antibody,Serine proteinase OMI Antibody,HTRA2 Antibody,OMI Antibody, PRSS25 Antibody

More alternative names for the antibody
High temperature requirement protein A2 antibody|HTRA 2 antibody|HtrA like serine protease antibody|HtrA serine peptidase 2 antibody|HtrA, E. coli, homolog of, 2 antibody|HtrA2 antibody|HTRA2_HUMAN antibody|mitochondrial antibody|Omi stress regulated endoprotease antibody|Omi stress-regulated endoprotease antibody|PARK 13 antibody|PARK13 antibody|Protease serine 25 antibody|PRSS 25 antibody|PRSS25 antibody|Serine protease 25 antibody|Serine protease HTRA2 antibody|Serine protease HTRA2 mitochondrial antibody|Serine protease htra2 mitochondrial precursor antibody|Serine protease omi antibody|Serine proteinase OMI antibody
Anti-HtrA2 / Omi antibody [E55] (ab32092)
Close sc-58371|sc-271528|sc-365594|sc-25606|sc-15467|

Recommended applications: ELISA, WB, IHC

Recommended dilution: Recommended dilution:WB:1:500-2000,IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-HTRA2 Antibody

Catalogue No.

CSB-PA010902ESR2HU

Reactivity

Human

Immunogen

Recombinant human Serine protease HTRA2, mitochondrial protein (334-458AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

Recommended dilution:WB:1:500-2000,IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

48 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:27429( Human), Entrez Gene:64704( Mouse), Entrez Gene:297376( Rat), Omim:606441( Human), SwissProt:O43464( Human), SwissProt:Q9JIY5( Mouse), Unigene:469045( Human), Unigene:744841( Human), Unigene:21880( Mouse), Unigene:107325( Rat)

Protein function

Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive. .

Protein tissue specificity

Isoform 1 is ubiquitous. Isoform 2 is expressed predominantly in the kidney, colon and thyroid.

Involvement in disease

Parkinson disease 13 (PARK13) [MIM:610297]: A complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. . Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the peptidase S1C family. The mature N-terminus is involved in the interaction with XIAP.; The PDZ domain mediates interaction with MXI2.

Protein post-translational modifications

Autoproteolytically activated.

Protein cellular localization

Mitochondrion intermembrane space. Mitochondrion membrane ; Single-pass membrane protein . Note=Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with caspase-8 truncated BID/tBID.

Research area

All research areas>Synthesis and Degradation>Htr
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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