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Rabbit Anti-IFNAR2 Antibody (CSB-PA011047ESR2HU)
Supplier: CUSABIO BIOTECH CO.
Interferon alpha/beta receptor 2 Antibody,IFN-R-2 Antibody,IFN-alpha binding protein Antibody,IFN-alpha/beta receptor 2 Antibody,Interferon alpha binding protein Antibody,Type I interferon receptor 2 Antibody,IFNAR2 Antibody,IFNABR Antibody, IFNARB AntibodyMore alternative names for the antibody
Human interferon alpha/beta receptor antibody|IFN alpha REC antibody|IFN R antibody|IFN-a/ßR2 antibody|IFN-a/ßRß antibody|IFN-alpha binding protein antibody|IFN-alpha/beta receptor 2 antibody|IFN-R-2 antibody|IFNABR antibody|IFNAR2 antibody|IFNARB antibody|IFNR antibody|INAR2_HUMAN antibody|Interferon (alpha beta and omega) receptor 2 antibody|Interferon alpha binding protein antibody|Interferon alpha/beta receptor 2 antibody|Interferon alpha/beta receptor beta chain antibody|Type I interferon receptor 2 antibody|Type I interferon receptor antibody
Anti-IFNAR2 antibody (ab56070)
Anti-IFNAR2 antibody (ab56070)
Recommended applications: ELISA, WB, IHC
Recommended dilution: Recommended dilution:WB:1:500-1000,IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Interferon alpha/beta receptor 2 protein (27-243AA)
ELISA, WB, IHC
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Protein function|| |
Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation (PubMed:26424569). Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1 (PubMed:8181059, PubMed:7665574, PubMed:7759950). Isoform 3 is a potent inhibitor of type I IFN receptor activity (PubMed:7759950). .
|Protein tissue specificity|| |
Isoform 3 is detected in the urine (at protein level) (PubMed:8181059, PubMed:7759950). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines. .
|Involvement in disease|| |
Immunodeficiency 45 (IMD45) [MIM:616669]: An autosomal recessive disorder characterized by increased susceptibility to viral infection due to impaired antiviral immunity, resulting in infection-associated encephalopathy. Affected individuals are at risk for developing fatal encephalitis after routine measles/mumps/rubella (MMR) vaccination. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the type II cytokine receptor family.
|Protein post-translational modifications|| |
Phosphorylated on tyrosine residues upon interferon binding. Phosphorylation at Tyr-337 or Tyr-512 are sufficient to mediate interferon dependent activation of STAT1, STAT2 and STAT3 leading to antiproliferative effects on many different cell types. .; Glycosylated. .
|Protein cellular localization|| |
Isoform 1: Cell membrane ; Single-pass type I membrane protein .; Isoform 2: Cell membrane ; Single-pass type I membrane protein .; Isoform 3: Secreted .
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CUSABIO BIOTECH CO.
|Product type|| |
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