Anti-IFNAR2 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-IFNAR2 Antibody (CSB-PA011047ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Interferon alpha/beta receptor 2 Antibody,IFN-R-2 Antibody,IFN-alpha binding protein Antibody,IFN-alpha/beta receptor 2 Antibody,Interferon alpha binding protein Antibody,Type I interferon receptor 2 Antibody,IFNAR2 Antibody,IFNABR Antibody, IFNARB Antibody

More alternative names for the antibody
Human interferon alpha/beta receptor antibody|IFN alpha REC antibody|IFN R antibody|IFN-a/ßR2 antibody|IFN-a/ßRß antibody|IFN-alpha binding protein antibody|IFN-alpha/beta receptor 2 antibody|IFN-R-2 antibody|IFNABR antibody|IFNAR2 antibody|IFNARB antibody|IFNR antibody|INAR2_HUMAN antibody|Interferon (alpha beta and omega) receptor 2 antibody|Interferon alpha binding protein antibody|Interferon alpha/beta receptor 2 antibody|Interferon alpha/beta receptor beta chain antibody|Type I interferon receptor 2 antibody|Type I interferon receptor antibody
Anti-IFNAR2 antibody (ab56070)
Close sc-704|sc-271105|sc-137209|sc-376273|sc-30014|sc-30015|sc-83256|

Recommended applications: ELISA, WB, IHC

Recommended dilution: Recommended dilution:WB:1:500-1000,IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-IFNAR2 Antibody

Catalogue No.

CSB-PA011047ESR2HU

Reactivity

Human

Immunogen

Recombinant human Interferon alpha/beta receptor 2 protein (27-243AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

Recommended dilution:WB:1:500-1000,IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

57 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:3455( Human), Omim:602376( Human), SwissProt:P48551( Human), Unigene:708195( Human)

Protein function

Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation (PubMed:26424569). Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1 (PubMed:8181059, PubMed:7665574, PubMed:7759950). Isoform 3 is a potent inhibitor of type I IFN receptor activity (PubMed:7759950). .

Protein tissue specificity

Isoform 3 is detected in the urine (at protein level) (PubMed:8181059, PubMed:7759950). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines. .

Involvement in disease

Immunodeficiency 45 (IMD45) [MIM:616669]: An autosomal recessive disorder characterized by increased susceptibility to viral infection due to impaired antiviral immunity, resulting in infection-associated encephalopathy. Affected individuals are at risk for developing fatal encephalitis after routine measles/mumps/rubella (MMR) vaccination. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the type II cytokine receptor family.

Protein post-translational modifications

Phosphorylated on tyrosine residues upon interferon binding. Phosphorylation at Tyr-337 or Tyr-512 are sufficient to mediate interferon dependent activation of STAT1, STAT2 and STAT3 leading to antiproliferative effects on many different cell types. .; Glycosylated. .

Protein cellular localization

Isoform 1: Cell membrane ; Single-pass type I membrane protein .; Isoform 2: Cell membrane ; Single-pass type I membrane protein .; Isoform 3: Secreted .

Research area

All research areas>Membrane Receptors>Interferon Receptor
(View all antibody categories related to Membrane Receptors)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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