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Rabbit Anti-IL1RAP Antibody (CSB-PA878844ESR1HU)
Supplier: CUSABIO BIOTECH CO.
IL-1 receptor accessory protein Antibody,IL-1RAcP Antibody,Interleukin-1 receptor 3 Antibody,IL-1R-3 Antibody,IL-1R3 Antibody,IL1RAP Antibody,C3orf13 Antibody,IL1R3 AntibodyMore alternative names for the antibody
C3orf13 antibody|FLJ37788 antibody|IL 1 receptor accessory protein antibody|IL 1R 3 antibody|IL 1R3 antibody|IL 1RAcP antibody|IL 1RAP antibody|IL-1 receptor accessory protein antibody|IL-1R-3 antibody|IL-1R3 antibody|IL-1RAcP antibody|IL1 receptor accessory protein antibody|IL1AP_HUMAN antibody|IL1R3 antibody|IL1RAcP antibody|Il1rap antibody|Interleukin 1 Accessory Protein antibody|interleukin 1 receptor 3 antibody|Interleukin 1 receptor accessory protein antibody|interleukin 1 receptor accessory protein beta antibody|Interleukin-1 receptor 3 antibody|Interleukin-1 receptor accessory protein antibody
Anti-IL1RAP antibody (ab8110)
Anti-IL1RAP antibody (ab8110)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Interleukin-1 receptor accessory protein (21-356AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:3556( Human), Entrez Gene:16180( Mouse), Entrez Gene:25466( Rat), Omim:602626( Human), SwissProt:Q9NPH3( Human), SwissProt:Q61730( Mouse), SwissProt:Q63621( Rat), Unigene:478673( Human), Unigene:253424( Mouse), Unigene:10511( Rat)
|Protein function|| |
Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. .; Isoform 2: Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (PubMed:12530978). Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling (By similarity). .; Isoform 4: Unable to mediate canonical IL-1 signaling (PubMed:19481478). Required for Src phosphorylation by IL1B. May be involved in IL1B-potentiated NMDA-induced calcium influx in neurons (By similarity). .
|Protein tissue specificity|| |
Detected in liver, skin, placenta, thymus and lung. Isoform 4 is predominantly expressed in brain. Overexpresed on candidate chronic myeloid leukemia (CML) stem cells, hematopoietic stem cells and mononuclear cells of patients with acute myeloid leukemia (AML). Overexpressed in patients with chronic obstructive pulmonary disease (COPD). .
|Protein sequence and domain|| |
Belongs to the interleukin-1 receptor family.
|Protein cellular localization|| |
Isoform 1: Cell membrane; Single-pass type I membrane protein.; Isoform 2: Secreted.; Isoform 3: Secreted.
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CUSABIO BIOTECH CO.
|Product type|| |
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