Anti-IL1RAP Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-IL1RAP Antibody (CSB-PA878844ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

IL-1 receptor accessory protein Antibody,IL-1RAcP Antibody,Interleukin-1 receptor 3 Antibody,IL-1R-3 Antibody,IL-1R3 Antibody,IL1RAP Antibody,C3orf13 Antibody,IL1R3 Antibody

More alternative names for the antibody
C3orf13 antibody|FLJ37788 antibody|IL 1 receptor accessory protein antibody|IL 1R 3 antibody|IL 1R3 antibody|IL 1RAcP antibody|IL 1RAP antibody|IL-1 receptor accessory protein antibody|IL-1R-3 antibody|IL-1R3 antibody|IL-1RAcP antibody|IL1 receptor accessory protein antibody|IL1AP_HUMAN antibody|IL1R3 antibody|IL1RAcP antibody|Il1rap antibody|Interleukin 1 Accessory Protein antibody|interleukin 1 receptor 3 antibody|Interleukin 1 receptor accessory protein antibody|interleukin 1 receptor accessory protein beta antibody|Interleukin-1 receptor 3 antibody|Interleukin-1 receptor accessory protein antibody
Anti-IL1RAP antibody (ab8110)
Close sc-376872|sc-99031|sc-47056|sc-47057|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-IL1RAP Antibody

Catalogue No.

CSB-PA878844ESR1HU

Reactivity

Human

Immunogen

Recombinant human Interleukin-1 receptor accessory protein (21-356AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

65 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:3556( Human), Entrez Gene:16180( Mouse), Entrez Gene:25466( Rat), Omim:602626( Human), SwissProt:Q9NPH3( Human), SwissProt:Q61730( Mouse), SwissProt:Q63621( Rat), Unigene:478673( Human), Unigene:253424( Mouse), Unigene:10511( Rat)

Protein function

Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. .; Isoform 2: Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (PubMed:12530978). Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling (By similarity). .; Isoform 4: Unable to mediate canonical IL-1 signaling (PubMed:19481478). Required for Src phosphorylation by IL1B. May be involved in IL1B-potentiated NMDA-induced calcium influx in neurons (By similarity). .

Protein tissue specificity

Detected in liver, skin, placenta, thymus and lung. Isoform 4 is predominantly expressed in brain. Overexpresed on candidate chronic myeloid leukemia (CML) stem cells, hematopoietic stem cells and mononuclear cells of patients with acute myeloid leukemia (AML). Overexpressed in patients with chronic obstructive pulmonary disease (COPD). .

Protein sequence and domain

Belongs to the interleukin-1 receptor family.

Protein cellular localization

Isoform 1: Cell membrane; Single-pass type I membrane protein.; Isoform 2: Secreted.; Isoform 3: Secreted.

Research area

All research areas>Membrane Receptors>IL-1R
(View all antibody categories related to Membrane Receptors)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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