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Rabbit Anti-IL21 Antibody (CSB-PA872537ESR1HU)
Supplier: CUSABIO BIOTECH CO.
IL-21 Antibody,Za11 Antibody,IL21 AntibodyMore alternative names for the antibody
CVID11 antibody|IL 21 antibody|IL-21 antibody|Il21 antibody|IL21_HUMAN antibody|Interleukin 21 antibody|Interleukin-21 antibody|interleukin-21 isoform antibody|Interleukin21 antibody|OTTHUMP00000164088 antibody|Za11 antibody
Anti-IL21 antibody (ab5978)
Anti-IL21 antibody (ab5978)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Interleukin-21 protein (25-162AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:59067( Human), Entrez Gene:60505( Mouse), Entrez Gene:365769( Rat), Omim:605384( Human), SwissProt:Q9HBE4( Human), SwissProt:Q9ES17( Mouse), SwissProt:A3QPB9( Rat), Unigene:567559( Human), Unigene:157689( Mouse), Unigene:214949( Rat)
|Protein function|| |
Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. .
|Protein tissue specificity|| |
Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes. .
|Involvement in disease|| |
Immunodeficiency, common variable, 11 (CVID11) [MIM:615767]: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the IL-15/IL-21 family.
|Protein cellular localization|| |
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CUSABIO BIOTECH CO.
|Product type|| |
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