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Rabbit Anti-IL27 Antibody (CSB-PA847702ESR1HU)
Supplier: CUSABIO BIOTECH CO.
IL-27 subunit alpha Antibody,IL-27-A Antibody,IL27-A Antibody,Interleukin-30 Antibody,IL27 Antibody,IL27A Antibody,IL30 AntibodyMore alternative names for the antibody
EBI3 antibody|IL 27 antibody|IL 27 p28 subunit antibody|IL 27A antibody|IL 30 antibody|IL-27 subunit alpha antibody|IL-27-A antibody|IL27 antibody|IL27-A antibody|IL27A antibody|IL27A_HUMAN antibody|IL27p28 antibody|IL30 antibody|Interleukin 27 antibody|Interleukin 27 subunit alpha antibody|Interleukin 27, 28-KD subunit antibody|Interleukin 30 antibody|Interleukin-27 subunit alpha antibody|p28 antibody
Anti-IL27 antibody – Aminoterminal end (ab62501)
Anti-IL27 antibody – Aminoterminal end (ab62501)
Recommended applications: ELISA, WB
Recommended dilution: Recommended dilution:WB:1:200-1000
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Interleukin-27 subunit alpha protein (29-243AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:246778( Human), Entrez Gene:246779( Mouse), Omim:608273( Human), SwissProt:Q14213( Human), SwissProt:Q8NEV9( Human), SwissProt:O35228( Mouse), SwissProt:Q8K3I6( Mouse), Unigene:528111( Human), Unigene:222632( Mouse)
|Protein function|| |
Associates with EBI3 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR which appears to be required but not sufficient for IL-27-mediated signal transduction. IL-27 potentiate the early phase of TH1 response and suppress TH2 and TH17 differentiation. It induces the differentiation of TH1 cells via two distinct pathways, p38 MAPK/TBX21- and ICAM1/ITGAL/ERK-dependent pathways. It also induces STAT1, STAT3, STAT4 and STAT5 phosphorylation and activates TBX21/T-Bet via STAT1 with resulting IL12RB2 up-regulation, an event crucial to TH1 cell commitment. It suppresses the expression of GATA3, the inhibitor TH1 cells development. In CD8 T-cells, it activates STATs as well as GZMB. IL-27 reveals to be a potent inhibitor of TH17 cell development and of IL-17 production. Indeed IL27 alone is also able to inhibit the production of IL17 by CD4 and CD8 T-cells. While IL-27 suppressed the development of proinflammatory Th17 cells via STAT1, it inhibits the development of anti-inflammatory inducible regulatory T-cells, iTreg, independently of STAT1. IL-27 has also an effect on cytokine production, it suppresses proinflammatory cytokine production such as IL2, IL4, IL5 and IL6 and activates suppressors of cytokine signaling such as SOCS1 and SOCS3. Apart from suppression of cytokine production, IL-27 also antagonizes the effects of some cytokines such as IL6 through direct effects on T-cells. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines such as IP-10/CXCL10 and MIG/CXCL9. In vein endothelial cells, it induces IRF1/interferon regulatory factor 1 and increase the expression of MHC class II transactivator/CIITA with resulting up-regulation of major histocompatibility complex class II. IL-27 also demonstrates antiviral activity with inhibitory properties on HIV-1 replication. .
|Protein tissue specificity|| |
Expressed in monocytes and in placenta. .
|Protein sequence and domain|| |
Belongs to the IL-6 superfamily.
|Protein post-translational modifications|| |
|Protein cellular localization|| |
Secreted . Note=Does not seem to be secreted without coexpression of EBI3.
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CUSABIO BIOTECH CO.
|Product type|| |
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