Anti-IL31RA Antibody

$309.00

Reactivity: Human,Mouse
Applications: ELISA,WB
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-IL31RA Antibody (CSB-PA854162ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Interleukin-31 receptor subunit alpha Antibody,IL-31 receptor subunit alpha Antibody,IL-31R subunit alpha Antibody,IL-31R-alpha Antibody,IL-31RA Antibody,Cytokine receptor-like 3 Antibody,GLM-R Antibody,hGLM-R Antibody,Gp130-like monocyte receptor Antibody,Gp130-like receptor Antibody,ZcytoR17 Antibody,IL31RA Antibody,CRL3 Antibody,GPL Antibody,UNQ6368/PRO21073/PRO21384 Antibody

More alternative names for the antibody
Class I cytokine receptor antibody|CRL 3 antibody|CRL antibody|CRL3 antibody|Cytokine receptor like 3 antibody|Cytokine receptor-like 3 antibody|GLM R antibody|GLM-R antibody|GLMR antibody|Gp130 like monocyte receptor antibody|GP130 like receptor antibody|Gp130-like monocyte receptor antibody|Gp130-like receptor antibody|GPL antibody|HGLM R antibody|HGLM-R antibody|HGLMR antibody|IL 31 receptor subunit alpha antibody|IL 31R subunit alpha antibody|IL 31RA antibody|IL-31 receptor subunit alpha antibody|IL-31R subunit alpha antibody|IL-31R-alpha antibody|IL-31RA antibody|IL31 receptor subunit alpha antibody|IL31R subunit alpha antibody|IL31R_HUMAN antibody|IL31RA antibody|Interleukin 31 receptor A antibody|interleukin 31 receptor subunit alpha antibody|Interleukin-31 receptor subunit alpha antibody|MGC125346 antibody|PLCA 2 antibody|PLCA2 antibody|PRO21384 antibody|Soluble type I cytokine receptor CRL3 antibody|ZcytoR17 antibody
Anti-TCCR antibody (ab5996)
Close sc-47066|sc-376309|sc-99083|sc-80078|

Recommended applications: ELISA, WB

Recommended dilution: User optimized

Recommended protocols: check protocols

Name

Anti-IL31RA Antibody

Catalogue No.

CSB-PA854162ESR2HU

Reactivity

Human, Mouse

Immunogen

Recombinant human Interleukin-31 receptor subunit alpha protein (1-300AA)

Host

Rabbit

Applications

ELISA, WB

Recommended dilution

User optimized

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

82 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:9466( Human), Entrez Gene:50931( Mouse), Entrez Gene:288905( Rat), Omim:605350( Human), SwissProt:Q6UWB1( Human), SwissProt:O70394( Mouse), Unigene:132781( Human), Unigene:38386( Mouse)

Protein function

Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5 (PubMed:11877449, PubMed:14504285, PubMed:15627637, PubMed:15194700). May function in skin immunity (PubMed:15184896). Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1 (By similarity). Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro (By similarity). .

Protein tissue specificity

Expressed in CD14- and CD56-positive blood cells (PubMed:11877449). Expressed in macrophages (PubMed:16461143, PubMed:18439099). Expressed in keratinocytes (PubMed:21261663). Expressed in a subset of dorsal root ganglia neurons (at protein level) (PubMed:24373353). Expressed at low levels in testis, ovary, brain, prostate, placenta, thymus, bone marrow, trachea and skin (PubMed:15184896, PubMed:11877449, PubMed:14504285). Expressed in bronchial and alveolar epithelial cells and pulmonary fibroblasts (PubMed:18439099). Detected in all of the myelomonocytic lineage (PubMed:14504285). Isoform 6: Expressed at higher levels in lesional skin compared to healthy skin of atopic dermatitis patients (PubMed:24373353). .

Involvement in disease

Amyloidosis, primary localized cutaneous, 2 (PLCA2) [MIM:613955]: A primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening that may be exacerbated by chronic scratching and rubbing. Primary localized cutaneous amyloidosis is often divided into macular and lichen subtypes although many affected individuals often show both variants coexisting. Lichen amyloidosis characteristically presents as a pruritic eruption of grouped hyperkeratotic papules with a predilection for the shins, calves, ankles and dorsa of feet and thighs. Papules may coalesce to form hyperkeratotic plaques that can resemble lichen planus, lichen simplex or nodular prurigo. Macular amyloidosis is characterized by small pigmented macules that may merge to produce macular hyperpigmentation, sometimes with a reticulate or rippled pattern. In macular and lichen amyloidosis, amyloid is deposited in the papillary dermis in association with grouped colloid bodies, thought to represent degenerate basal keratinocytes. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the type I cytokine receptor family. Type 2 subfamily.

Protein post-translational modifications

N-glycosylated. .

Protein cellular localization

Cell membrane ; Single-pass type I membrane protein . Cell junction, synapse, presynaptic cell membrane . Cell projection, axon .

Research area

All research areas>Membrane Receptors>IL-31R
(View all antibody categories related to Membrane Receptors)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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