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Rabbit Anti-IL31RA Antibody (CSB-PA854162ESR2HU)
Supplier: CUSABIO BIOTECH CO.
Interleukin-31 receptor subunit alpha Antibody,IL-31 receptor subunit alpha Antibody,IL-31R subunit alpha Antibody,IL-31R-alpha Antibody,IL-31RA Antibody,Cytokine receptor-like 3 Antibody,GLM-R Antibody,hGLM-R Antibody,Gp130-like monocyte receptor Antibody,Gp130-like receptor Antibody,ZcytoR17 Antibody,IL31RA Antibody,CRL3 Antibody,GPL Antibody,UNQ6368/PRO21073/PRO21384 AntibodyMore alternative names for the antibody
Class I cytokine receptor antibody|CRL 3 antibody|CRL antibody|CRL3 antibody|Cytokine receptor like 3 antibody|Cytokine receptor-like 3 antibody|GLM R antibody|GLM-R antibody|GLMR antibody|Gp130 like monocyte receptor antibody|GP130 like receptor antibody|Gp130-like monocyte receptor antibody|Gp130-like receptor antibody|GPL antibody|HGLM R antibody|HGLM-R antibody|HGLMR antibody|IL 31 receptor subunit alpha antibody|IL 31R subunit alpha antibody|IL 31RA antibody|IL-31 receptor subunit alpha antibody|IL-31R subunit alpha antibody|IL-31R-alpha antibody|IL-31RA antibody|IL31 receptor subunit alpha antibody|IL31R subunit alpha antibody|IL31R_HUMAN antibody|IL31RA antibody|Interleukin 31 receptor A antibody|interleukin 31 receptor subunit alpha antibody|Interleukin-31 receptor subunit alpha antibody|MGC125346 antibody|PLCA 2 antibody|PLCA2 antibody|PRO21384 antibody|Soluble type I cytokine receptor CRL3 antibody|ZcytoR17 antibody
Anti-TCCR antibody (ab5996)
Anti-TCCR antibody (ab5996)
Recommended applications: ELISA, WB
Recommended dilution: User optimized
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Interleukin-31 receptor subunit alpha protein (1-300AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Protein function|| |
Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5 (PubMed:11877449, PubMed:14504285, PubMed:15627637, PubMed:15194700). May function in skin immunity (PubMed:15184896). Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1 (By similarity). Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro (By similarity). .
|Protein tissue specificity|| |
Expressed in CD14- and CD56-positive blood cells (PubMed:11877449). Expressed in macrophages (PubMed:16461143, PubMed:18439099). Expressed in keratinocytes (PubMed:21261663). Expressed in a subset of dorsal root ganglia neurons (at protein level) (PubMed:24373353). Expressed at low levels in testis, ovary, brain, prostate, placenta, thymus, bone marrow, trachea and skin (PubMed:15184896, PubMed:11877449, PubMed:14504285). Expressed in bronchial and alveolar epithelial cells and pulmonary fibroblasts (PubMed:18439099). Detected in all of the myelomonocytic lineage (PubMed:14504285). Isoform 6: Expressed at higher levels in lesional skin compared to healthy skin of atopic dermatitis patients (PubMed:24373353). .
|Involvement in disease|| |
Amyloidosis, primary localized cutaneous, 2 (PLCA2) [MIM:613955]: A primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening that may be exacerbated by chronic scratching and rubbing. Primary localized cutaneous amyloidosis is often divided into macular and lichen subtypes although many affected individuals often show both variants coexisting. Lichen amyloidosis characteristically presents as a pruritic eruption of grouped hyperkeratotic papules with a predilection for the shins, calves, ankles and dorsa of feet and thighs. Papules may coalesce to form hyperkeratotic plaques that can resemble lichen planus, lichen simplex or nodular prurigo. Macular amyloidosis is characterized by small pigmented macules that may merge to produce macular hyperpigmentation, sometimes with a reticulate or rippled pattern. In macular and lichen amyloidosis, amyloid is deposited in the papillary dermis in association with grouped colloid bodies, thought to represent degenerate basal keratinocytes. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the type I cytokine receptor family. Type 2 subfamily.
|Protein post-translational modifications|| |
|Protein cellular localization|| |
Cell membrane ; Single-pass type I membrane protein . Cell junction, synapse, presynaptic cell membrane . Cell projection, axon .
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CUSABIO BIOTECH CO.
|Product type|| |
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