Anti-IL36A Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-IL36A Antibody (CSB-PA887028ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Interleukin-36 alpha Antibody,FIL1 epsilon Antibody,Interleukin-1 epsilon Antibody,IL-1 epsilon Antibody,Interleukin-1 family member 6 Antibody,IL-1F6 Antibody,IL36A Antibody,FIL1E Antibody,IL1E Antibody,IL1F6 Antibody

More alternative names for the antibody
FIL1 antibody|FIL1 epsilon antibody|FIL1(EPSILON) antibody|FIL1E antibody|IL 1 epsilon antibody|IL 1F6 antibody|IL 1H1 antibody|IL-1 epsilon antibody|IL-1F6 antibody|IL1E antibody|IL1F6 antibody|IL1F6_HUMAN antibody|IL1RP2 antibody|IL36A antibody|Interleukin 1 epsilon antibody|Interleukin 1 family member 6 (epsilon) antibody|Interleukin 1 family member 6 antibody|Interleukin 36 alpha antibody|Interleukin-1 epsilon antibody|Interleukin-1 family member 6 antibody|MGC129552 antibody|MGC129553 antibody|MGC151479 antibody|MGC151481 antibody|OTTMUSP00000012798 antibody|RP23-176J12.4 antibody
Anti-IL37 antibody (ab57187)
Close sc-517072|sc-168152|sc-168153|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-IL36A Antibody

Catalogue No.

CSB-PA887028ESR2HU

Reactivity

Human

Immunogen

Recombinant human Interleukin-36 alpha protein (1-158AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

17 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:27178( Human), Omim:605510( Human), SwissProt:Q9NZH6( Human), Unigene:166371( Human)

Protein function

Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6. In cultured monocytes upregulates expression of IL-1A, IL-1B and IL-6. In myeloid dendritic cells involved in cell maturation by upregulating surface expression of CD83, CD86 and HLA-DR. In monocyte-derived dendritic cells facilitates dendritic cell maturation and drives T-cell proliferation. May play a role in proinflammatory effects in the lung. .

Protein tissue specificity

Expressed in immune system and fetal brain, but not in other tissues tested or in multiple hematopoietic cell lines. Predominantly expressed in skin keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Increased in lesional psoriasis skin. .

Protein sequence and domain

Belongs to the IL-1 family.

Protein post-translational modifications

N-terminal truncation leads to a dramatic enhancement of its activity (>1000-fold). .

Protein cellular localization

Secreted .

Research area

All research areas>Membrane Receptors>IL-1F
(View all antibody categories related to Membrane Receptors)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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