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Rabbit Anti-IL36A Antibody (CSB-PA887028ESR2HU)
Supplier: CUSABIO BIOTECH CO.
Interleukin-36 alpha Antibody,FIL1 epsilon Antibody,Interleukin-1 epsilon Antibody,IL-1 epsilon Antibody,Interleukin-1 family member 6 Antibody,IL-1F6 Antibody,IL36A Antibody,FIL1E Antibody,IL1E Antibody,IL1F6 AntibodyMore alternative names for the antibody
FIL1 antibody|FIL1 epsilon antibody|FIL1(EPSILON) antibody|FIL1E antibody|IL 1 epsilon antibody|IL 1F6 antibody|IL 1H1 antibody|IL-1 epsilon antibody|IL-1F6 antibody|IL1E antibody|IL1F6 antibody|IL1F6_HUMAN antibody|IL1RP2 antibody|IL36A antibody|Interleukin 1 epsilon antibody|Interleukin 1 family member 6 (epsilon) antibody|Interleukin 1 family member 6 antibody|Interleukin 36 alpha antibody|Interleukin-1 epsilon antibody|Interleukin-1 family member 6 antibody|MGC129552 antibody|MGC129553 antibody|MGC151479 antibody|MGC151481 antibody|OTTMUSP00000012798 antibody|RP23-176J12.4 antibody
Anti-IL37 antibody (ab57187)
Anti-IL37 antibody (ab57187)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Interleukin-36 alpha protein (1-158AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=27178" target="_blank">Entrez Gene:27178( Human)</a>, <a href="http://www.ncbi.nlm.nih.gov/omim/605510" target="_blank">Omim:605510( Human)</a>, <a href="http://www.uniprot.org/uniprot/Q9NZH6" target="_blank">SwissProt:Q9NZH6( Human)</a>, <a href="http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=166371" target="_blank">Unigene:166371( Human)</a>
|Protein function|| |
Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6. In cultured monocytes upregulates expression of IL-1A, IL-1B and IL-6. In myeloid dendritic cells involved in cell maturation by upregulating surface expression of CD83, CD86 and HLA-DR. In monocyte-derived dendritic cells facilitates dendritic cell maturation and drives T-cell proliferation. May play a role in proinflammatory effects in the lung. .
|Protein tissue specificity|| |
Expressed in immune system and fetal brain, but not in other tissues tested or in multiple hematopoietic cell lines. Predominantly expressed in skin keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Increased in lesional psoriasis skin. .
|Protein sequence and domain|| |
Belongs to the IL-1 family.
|Protein post-translational modifications|| |
N-terminal truncation leads to a dramatic enhancement of its activity (>1000-fold). .
|Protein cellular localization|| |
|Research area|| |
<a href="https://antibodyplus.com/research-areas/">All research areas</a>><a href="https://antibodyplus.com/Membrane-Receptors/">Membrane Receptors</a>><a href="https://antibodyplus.com/product-tag/IL-1F/">IL-1F</a><br><a href="https://antibodyplus.com/product-tag/Membrane-Receptors/"> (View all antibody categories related to Membrane Receptors)</a>
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CUSABIO BIOTECH CO.
|Product type|| |
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