Anti-IL36G Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-IL36G Antibody (CSB-PA873706ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Interleukin-36 gamma Antibody,IL-1-related protein 2 Antibody,IL-1RP2 Antibody,Interleukin-1 epsilon Antibody,IL-1 epsilon Antibody,Interleukin-1 family member 9 Antibody,IL-1F9 Antibody,Interleukin-1 homolog 1 Antibody,IL-1H1 Antibody,IL36G Antibody,IL1E Antibody,IL1F9 Antibody,IL1H1 Antibody,IL1RP2 Antibody,UNQ2456/PRO5737 Antibody

More alternative names for the antibody
IL 1 epsilon antibody|IL 1(EPSILON) antibody|IL-1F9 antibody|Interleukin 36 gamma antibody|Interleukin-1 epsilon antibody|Interleukin-1 family member 9 antibody|Interleukin-1 homolog 1 antibody
Anti-IL36 gamma antibody [2F4] (ab156783)
Close sc-168161|sc-168163|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-IL36G Antibody

Catalogue No.

CSB-PA873706ESR2HU

Reactivity

Human

Immunogen

Recombinant human Interleukin-36 gamma protein (1-169AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

18 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:56300( Human), Omim:605542( Human), SwissProt:Q9NZH8( Human), Unigene:211238( Human)

Protein function

Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1; also stimulates its own expression and that of the prototypic cutaneous proinflammatory parameters TNF-alpha, S100A7/psoriasin and inducible NOS. May play a role in proinflammatory responses during particular neutrophilic airway inflammation: activates mitogen-activated protein kinases and NF-kappa B in primary lung fibroblasts, and stimulates the expression of IL-8 and CXCL3 and Th17 chemokine CCL20 in lung fibroblasts. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. .

Protein tissue specificity

Highly expressed in tissues containing epithelial cells: skin, lung, stomach and esophagus. Expressed in bronchial epithelial. In skin is expressed only in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Up-regulated in lesional psoriasis skin. Expressed in monocyte-derived dendritic cells and M1 macrophages. .

Protein sequence and domain

Belongs to the IL-1 family.

Protein post-translational modifications

N-terminal truncation leads to a dramatic enhancement of its activity (>1000-fold). .

Protein cellular localization

Secreted .

Research area

All research areas>Membrane Receptors>IL-1F
(View all antibody categories related to Membrane Receptors)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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