Anti-ILF3 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-ILF3 Antibody (CSB-PA613273ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Double-stranded RNA-binding protein 76 Antibody,DRBP76 Antibody,M-phase phosphoprotein 4 Antibody,MPP4 Antibody,Nuclear factor associated with dsRNA Antibody,NFAR Antibody,Nuclear factor of activated T-cells 90 kDa Antibody,NF-AT-90 Antibody,Translational control protein 80 Antibody,TCP80 Antibody

More alternative names for the antibody
CBTF antibody|Double stranded RNA binding protein 76 antibody|Double-stranded RNA-binding protein 76 antibody|DRBF antibody|DRBP76 antibody|ILF3 antibody|ILF3_HUMAN antibody|Interleukin enhancer binding factor 3 antibody|Interleukin enhancer-binding factor 3 antibody|M phase phosphoprotein 4 antibody|M-phase phosphoprotein 4 antibody|MPHOSPH4 antibody|MPP4 antibody|NF AT 90 antibody|NF-AT-90 antibody|NF110 antibody|NF90 antibody|NFAR antibody|Nuclear factor associated with dsRNA antibody|Nuclear factor of activated T cells 90 kDa antibody|Nuclear factor of activated T-cells 90 kDa antibody|TCP80 antibody|Translational control protein 80 antibody
Anti-ILF3 antibody [EPR3626] (ab92355)
Close sc-136197|sc-377406|sc-22530|

Recommended applications: ELISA, WB, IHC

Recommended dilution: Recommended dilution:WB:1:200-1000,IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-ILF3 Antibody

Catalogue No.

CSB-PA613273ESR1HU

Reactivity

Human

Immunogen

Recombinant human Interleukin enhancer-binding factor 3 protein (785-894AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

Recommended dilution:WB:1:200-1000,IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

95 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:3609( Human), Entrez Gene:16201( Mouse), Omim:603182( Human), SwissProt:Q12906( Human), SwissProt:Q9Z1X4( Mouse), Unigene:465885( Human), Unigene:440026( Mouse)

Protein function

May facilitate double-stranded RNA-regulated gene expression at the level of post-transcription. Can act as a translation inhibitory protein which binds to coding sequences of acid beta-glucosidase (GCase) and other mRNAs and functions at the initiation phase of GCase mRNA translation, probably by inhibiting its binding to polysomes. Can regulate protein arginine N-methyltransferase 1 activity. May regulate transcription of the IL2 gene during T-cell activation. Can promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. The phosphorylated form at Thr-188 and Thr-315, in concert with EIF2AK2/PKR can inhibit vesicular stomatitis virus (VSV) replication (By similarity). .

Protein tissue specificity

Ubiquitous.

Protein post-translational modifications

Phosphorylated at Thr-188 and Thr-315 by PKR in response to certain RNA viruses. This phosphorylation results in the dissociation of ILF2 from the ILF2-ILF3 complex resulting in a cytoplasmic sequestration of ILF3 where it can bind to viral RNAs and impede viral replication. .; Methylated by protein arginine N-methyltransferase 1.; Arg-609 is dimethylated, probably to asymmetric dimethylarginine.

Protein cellular localization

Nucleus, nucleolus. Cytoplasm. Nucleus. Note=Localizes in the cytoplasm in response to viral dsRNA. The unphosphorylated form is retained in the nucleus by ILF2. Phosphorylation at Thr-188 and Thr-315 causes the dissociation of ILF2 from the ILF2-ILF3 complex resulting in a cytoplasmic sequestration of ILF3. Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Research area

All research areas>Transcription Regulators>NF90
(View all antibody categories related to Transcription Regulators)

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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