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Rabbit Anti-IRAK4 Antibody (CSB-PA011812ESR1HU)
Supplier: CUSABIO BIOTECH CO.
IRAK-4 Antibody,Renal carcinoma antigen NY-REN-64 Antibody,IRAK4 AntibodyMore alternative names for the antibody
IL-1 receptor-associated kinase 4 antibody|Interleukin 1 receptor associated kinase 4 mutant form 1 antibody|Interleukin-1 receptor-associated kinase 4 antibody|Interleukin1 receptor associated kinase 4 antibody|IPD1 antibody|IRAK 4 antibody|IRAK-4 antibody|IRAK4 antibody|IRAK4 mutated form 1 antibody|IRAK4_HUMAN antibody|LOC 51135 antibody|NY REN 64 antibody|NY REN 64 antigen antibody|NY-REN-64 antibody|REN64 antibody|Renal carcinoma antigen NY-REN-64 antibody
Anti-IRAK4 antibody [2H9] (ab119942)
Anti-IRAK4 antibody [2H9] (ab119942)
Recommended applications: ELISA, WB
Recommended dilution: Recommended dilution:WB:1:500-2000
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Interleukin-1 receptor-associated kinase 4 protein (1-220AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Protein function|| |
Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways (PubMed:17878374). Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections. .
|Involvement in disease|| |
Recurrent isolated invasive pneumococcal disease 1 (IPD1) [MIM:610799]: Recurrent invasive pneumococcal disease (IPD) is defined as two episodes of IPD occurring at least 1 month apart, whether caused by the same or different serotypes or strains. Recurrent IPD occurs in at least 2% of patients in most series, making IPD the most important known risk factor for subsequent IPD. . Note=The disease is caused by mutations affecting the gene represented in this entry.; IRAK4 deficiency (IRAK4D) [MIM:607676]: Causes extracellular pyogenic bacterial and fungal infections in otherwise healthy children. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
|Protein post-translational modifications|| |
|Protein cellular localization|| |
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|Product type|| |
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