Anti-IRF4 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit Anti-IRF4 Antibody (CSB-PA011819ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

IRF-4 Antibody,Lymphocyte-specific interferon regulatory factor Antibody, LSIRF Antibody,Multiple myeloma oncogene 1 Antibody,NF-EM5 Antibody,IRF4 Antibody,MUM1 Antibody

More alternative names for the antibody
Interferon regulatory factor 4 antibody|IRF 4 antibody|IRF-4 antibody|Irf4 antibody|IRF4_HUMAN antibody|LSIRF antibody|Lymphocyte specific interferon regulatory factor antibody|Lymphocyte specific IRF antibody|Lymphocyte-specific interferon regulatory factor antibody|Multiple myeloma oncogene 1 antibody|MUM 1 antibody|MUM1 antibody|NF EM5 antibody|NF-EM5 antibody|NFEM5 antibody|PU.1 interaction partner antibody|Sfpi1/PU.1 interaction partner antibody|Transcriptional activator PIP antibody
Anti-MUM1 antibody [EP5699] (ab133590)
Close sc-130921|sc-377383|sc-48338|sc-28696|sc-6059|sc-56713|sc-11450|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-IRF4 Antibody

Catalogue No.

CSB-PA011819ESR2HU

Reactivity

Human

Immunogen

Recombinant human Interferon regulatory factor 4 protein (180-451AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

51 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:3662( Human), Omim:601900( Human), SwissProt:Q15306( Human), Unigene:401013( Human)

Protein function

Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5′-TGAnTCA/GAAA-3′), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes (By similarity). .

Protein tissue specificity

Lymphoid cells.

Involvement in disease

Multiple myeloma (MM) [MIM:254500]: A malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. . Note=The gene represented in this entry may be involved in disease pathogenesis. A chromosomal aberration involving IRF4 has been found in multiple myeloma. Translocation t(6;14)(p25;q32) with the IgH locus.

Protein sequence and domain

Belongs to the IRF family.

Protein post-translational modifications

Phosphorylation by ROCK2 regulates IL-17 and IL-21 production. .

Protein cellular localization

Nucleus.

Research area

All research areas>Transcription Regulators>IRF
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!