Anti-IRF8 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-IRF8 Antibody (CSB-PA011823ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

IRF-8 Antibody,Interferon consensus sequence-binding protein Antibody,H-ICSBP Antibody,ICSBP Antibody,IRF8 Antibody,ICSBP1 Antibody

More alternative names for the antibody
H ICSBP antibody|H-ICSBP antibody|HGNC:5358 antibody|HICSBP antibody|ICSBP 1 antibody|ICSBP antibody|ICSBP1 antibody|Interferon consensus sequence binding protein 1 antibody|Interferon consensus sequence binding protein antibody|Interferon consensus sequence-binding protein antibody|Interferon regulatory factor 8 antibody|IRF 8 antibody|IRF-8 antibody|Irf8 antibody|IRF8_HUMAN antibody|MYLS antibody
Anti-IRF8 antibody (ab28696)
Close sc-393676|sc-6058|sc-365042|sc-398237|sc-365041|sc-393955|sc-13043|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-IRF8 Antibody

Catalogue No.

CSB-PA011823ESR2HU

Reactivity

Human

Immunogen

Recombinant human Interferon regulatory factor 8 protein (137-426AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

48 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:614909( Cow), Entrez Gene:489673( Dog), Entrez Gene:3394( Human), Entrez Gene:15900( Mouse), Entrez Gene:292060( Rat), Omim:601565( Human), SwissProt:Q02556( Human), SwissProt:P23611( Mouse), Unigene:137427( Human), Unigene:334861( Mouse), Unigene:228738( Rat)

Protein function

Plays a role as a transcriptional activator or repressor (PubMed:25122610). Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5′-TGAnTCA/GAAA-3′), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (By similarity). .

Protein tissue specificity

Predominantly expressed in lymphoid tissues. .

Involvement in disease

Immunodeficiency 32A (IMD32A) [MIM:614893]: An immunologic disorder characterized by abnormal peripheral blood myeloid phenotype with a marked loss of CD11C-positive/CD1C dendritic cells, resulting in selective susceptibility to mycobacterial infections. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Immunodeficiency 32B (IMD32B) [MIM:614894]: A life-threatening pediatric disease characterized by monocyte and dendritic cell deficiency, myeloproliferation, and susceptibility to severe opportunistic infections, including disseminated BCG infection and oral candidiasis. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the IRF family.

Protein post-translational modifications

Ubiquitinated (PubMed:25122610). Ubiquitination by TRIM21 in macrophages, a process that is strongly increased upon interferon gamma stimulation, leds to the enhanced transcriptional activity of target cytokine genes (By similarity). Ubiquitination leads to its degradation by the proteasome (PubMed:25122610). .; Sumoylated with SUMO3. Desumoylated by SENP1. .

Protein cellular localization

Nucleus . Cytoplasm . Note=In resting macrophages, localizes in the cytoplasm. Translocated in the nucleus upon IFN-gamma induction. .

Research area

All research areas>Transcription Regulators>ICSBP
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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