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Rabbit Anti-IRF8 Antibody (CSB-PA011823ESR2HU)
Supplier: CUSABIO BIOTECH CO.
IRF-8 Antibody,Interferon consensus sequence-binding protein Antibody,H-ICSBP Antibody,ICSBP Antibody,IRF8 Antibody,ICSBP1 AntibodyMore alternative names for the antibody
H ICSBP antibody|H-ICSBP antibody|HGNC:5358 antibody|HICSBP antibody|ICSBP 1 antibody|ICSBP antibody|ICSBP1 antibody|Interferon consensus sequence binding protein 1 antibody|Interferon consensus sequence binding protein antibody|Interferon consensus sequence-binding protein antibody|Interferon regulatory factor 8 antibody|IRF 8 antibody|IRF-8 antibody|Irf8 antibody|IRF8_HUMAN antibody|MYLS antibody
Anti-IRF8 antibody (ab28696)
Anti-IRF8 antibody (ab28696)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Interferon regulatory factor 8 protein (137-426AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:614909( Cow), Entrez Gene:489673( Dog), Entrez Gene:3394( Human), Entrez Gene:15900( Mouse), Entrez Gene:292060( Rat), Omim:601565( Human), SwissProt:Q02556( Human), SwissProt:P23611( Mouse), Unigene:137427( Human), Unigene:334861( Mouse), Unigene:228738( Rat)
|Protein function|| |
Plays a role as a transcriptional activator or repressor (PubMed:25122610). Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5′-TGAnTCA/GAAA-3′), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (By similarity). .
|Protein tissue specificity|| |
Predominantly expressed in lymphoid tissues. .
|Involvement in disease|| |
Immunodeficiency 32A (IMD32A) [MIM:614893]: An immunologic disorder characterized by abnormal peripheral blood myeloid phenotype with a marked loss of CD11C-positive/CD1C dendritic cells, resulting in selective susceptibility to mycobacterial infections. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Immunodeficiency 32B (IMD32B) [MIM:614894]: A life-threatening pediatric disease characterized by monocyte and dendritic cell deficiency, myeloproliferation, and susceptibility to severe opportunistic infections, including disseminated BCG infection and oral candidiasis. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the IRF family.
|Protein post-translational modifications|| |
Ubiquitinated (PubMed:25122610). Ubiquitination by TRIM21 in macrophages, a process that is strongly increased upon interferon gamma stimulation, leds to the enhanced transcriptional activity of target cytokine genes (By similarity). Ubiquitination leads to its degradation by the proteasome (PubMed:25122610). .; Sumoylated with SUMO3. Desumoylated by SENP1. .
|Protein cellular localization|| |
Nucleus . Cytoplasm . Note=In resting macrophages, localizes in the cytoplasm. Translocated in the nucleus upon IFN-gamma induction. .
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CUSABIO BIOTECH CO.
|Product type|| |
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