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Rabbit Anti-ITGB3BP Antibody (CSB-PA622653DSR1HU)
Supplier: CUSABIO BIOTECH CO.
Centromere protein R Antibody,CENP-R Antibody,Beta-3-endonexin Antibody,Integrin beta-3-binding protein Antibody,Nuclear receptor-interacting factor 3 Antibody,ITGB3BP Antibody,CENPR Antibody,NRIF3 AntibodyMore alternative names for the antibody
Beta 3 endonexin antibody|Beta3 endonexin antibody|Beta3 endonexin long form antibody|CENP R antibody|CENPR antibody|CENPR_HUMAN antibody|Centromere protein R antibody|endonexin, Beta-3 antibody|HSU37139 antibody|Integrin beta 3 binding protein (beta3-endonexin) antibody|Integrin beta 3 binding protein antibody|NRIF 3 antibody|NRIF3 antibody|Nuclear receptor interacting factor 3 antibody|TAP 20 antibody|TAP20 antibody
Anti-ITGB3BP antibody (ab82764)
Anti-ITGB3BP antibody (ab82764)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Centromere protein R protein (1-177AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23421" target="_blank">Entrez Gene:23421( Human)</a>, <a href="http://www.ncbi.nlm.nih.gov/omim/605494" target="_blank">Omim:605494( Human)</a>, <a href="http://www.uniprot.org/uniprot/Q13352" target="_blank">SwissProt:Q13352( Human)</a>, <a href="http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=166539" target="_blank">Unigene:166539( Human)</a>
|Protein function|| |
Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A-associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. .
|Protein tissue specificity|| |
Widely expressed. Expressed in spleen, thymus, prostate, ovary, small intestine and white blood cells. Highly expressed in testis and colon. Isoform 4 is expressed in platelets, lymphocytes and granulocytes. .
|Protein sequence and domain|| |
The DD1 domain (also called RepD1 domain) mediates the corepressor function and is essential in the triggering of apoptosis.; Contains one Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, a motif known to be important for the association with nuclear receptors. Such motif, which is required for an efficient association with nuclear receptors, is however not essential.; Contains one Leu-Xaa-Xaa-Ile-Leu (LXXIL) motif, which is essential for the association with nuclear receptors.
|Protein cellular localization|| |
Isoform 1: Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore.; Isoform 2: Nucleus.; Isoform 3: Nucleus. Cytoplasm. Note=Isoform 3 is predominantly nuclear and weakly cytoplasmic.; Isoform 4: Cytoplasm.
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CUSABIO BIOTECH CO.
|Product type|| |
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