Anti-ITGB3BP Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-ITGB3BP Antibody (CSB-PA622653DSR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Centromere protein R Antibody,CENP-R Antibody,Beta-3-endonexin Antibody,Integrin beta-3-binding protein Antibody,Nuclear receptor-interacting factor 3 Antibody,ITGB3BP Antibody,CENPR Antibody,NRIF3 Antibody

More alternative names for the antibody
Beta 3 endonexin antibody|Beta3 endonexin antibody|Beta3 endonexin long form antibody|CENP R antibody|CENPR antibody|CENPR_HUMAN antibody|Centromere protein R antibody|endonexin, Beta-3 antibody|HSU37139 antibody|Integrin beta 3 binding protein (beta3-endonexin) antibody|Integrin beta 3 binding protein antibody|NRIF 3 antibody|NRIF3 antibody|Nuclear receptor interacting factor 3 antibody|TAP 20 antibody|TAP20 antibody
Anti-ITGB3BP antibody (ab82764)
Close sc-101092|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-ITGB3BP Antibody

Catalogue No.

CSB-PA622653DSR1HU

Reactivity

Human

Immunogen

Recombinant human Centromere protein R protein (1-177AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

20 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:23421( Human), Omim:605494( Human), SwissProt:Q13352( Human), Unigene:166539( Human)

Protein function

Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A-associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. .

Protein tissue specificity

Widely expressed. Expressed in spleen, thymus, prostate, ovary, small intestine and white blood cells. Highly expressed in testis and colon. Isoform 4 is expressed in platelets, lymphocytes and granulocytes. .

Protein sequence and domain

The DD1 domain (also called RepD1 domain) mediates the corepressor function and is essential in the triggering of apoptosis.; Contains one Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, a motif known to be important for the association with nuclear receptors. Such motif, which is required for an efficient association with nuclear receptors, is however not essential.; Contains one Leu-Xaa-Xaa-Ile-Leu (LXXIL) motif, which is essential for the association with nuclear receptors.

Protein cellular localization

Isoform 1: Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore.; Isoform 2: Nucleus.; Isoform 3: Nucleus. Cytoplasm. Note=Isoform 3 is predominantly nuclear and weakly cytoplasmic.; Isoform 4: Cytoplasm.

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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