Anti-ITGB7 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-ITGB7 Antibody (CSB-PA011891ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Integrin beta-7 Antibody,Gut homing receptor beta subunit Antibody,ITGB7 Antibody

More alternative names for the antibody
Gut homing receptor beta subunit antibody|Integrin beta 7 subunit antibody|Integrin beta-7 antibody|Integrin beta-P antibody|Integrin, beta 7 antibody|ITB7 antibody|ITB7_HUMAN antibody|Itgb7 antibody|Ly69 antibody|M290 IEL antigen antibody
Anti-Integrin beta 7 antibody (Biotin) [FIB504] Close sc-6637|sc-23919|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-ITGB7 Antibody

Catalogue No.

CSB-PA011891ESR2HU

Reactivity

Human

Immunogen

Recombinant human Integrin beta-7 protein (1-140AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

86 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:3695( Human), Entrez Gene:16421( Mouse), Omim:147559( Human), SwissProt:P26010( Human), SwissProt:P26011( Mouse), Unigene:654470( Human), Unigene:58( Mouse)

Protein function

Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.

Protein tissue specificity

Expressed in a variety of leukocyte lines.

Protein sequence and domain

Belongs to the integrin beta chain family. Domain I contains three cation-binding sites: the ligand-integrin-binding site (LIMBS), the metal ion-dependent adhesion site (MIDAS), and the adjacent to MIDAS site (ADMIDAS). In the absence of a ligand or in calcium-dependent binding, only ADMIDAS is occupied. In magnesium-dependent binding all three sites bind metal ions. LIMBS positively modify ligand binding whereas ADMIDAS negatively modify ligand binding.

Protein cellular localization

Membrane; Single-pass type I membrane protein.

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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