Anti-ITPK1 Antibody

$99.00$319.00

Reactivity: Human,Mouse
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-ITPK1 Antibody (CSB-PA613412ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Inositol-tetrakisphosphate 1-kinase Antibody,Inositol 1 Antibody,3 Antibody,4-trisphosphate 5/6-kinase Antibody,Inositol-triphosphate 5/6-kinase Antibody,Ins(1 Antibody,3 Antibody,4)P(3) 5/6-kinase Antibody,ITPK1 Antibody

More alternative names for the antibody
3 antibody|4)P(3) 5/6-kinase antibody|4-trisphosphate 5/6-kinase antibody|Inositol 1 3 4 triphosphate 5/6 kinase antibody|Inositol 1 3 4 trisphosphate 5/6 kinase antibody|Inositol 1 antibody|Inositol tetrakisphosphate 1 kinase antibody|Inositol triphosphate 5/6 kinase antibody|Inositol-tetrakisphosphate 1-kinase antibody|Inositol-triphosphate 5/6-kinase antibody|Ins(1 3 4)P(3) 5/6 kinase antibody|Ins(1 antibody|ITPK 1 antibody|itpk1 antibody|ITPK1_HUMAN antibody|ITRPK 1 antibody|ITRPK1 antibody
Anti-ITPK1 antibody [EPR10631] (ab175222)
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Recommended applications: ELISA, WB, IHC

Recommended dilution: User optimized

Recommended protocols: check protocols

Name

Anti-ITPK1 Antibody

Catalogue No.

CSB-PA613412ESR2HU

Reactivity

Human, Mouse

Immunogen

Recombinant human Inositol-tetrakisphosphate 1-kinase protein (185-414AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

User optimized

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

45 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:3705( Human), Omim:601838( Human), SwissProt:Q13572( Human), Unigene:308122( Human)

Protein function

Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain. .

Protein tissue specificity

Expressed in brain > heart > skeletal muscle = kidney = pancreas = liver = placenta > lung. In brain, it is expressed in cerebellum, cerebral cortex, medulla, spinal cord, occipital lobe, frontal lobe, temporal lobe and putamen. .

Protein sequence and domain

Belongs to the ITPK1 family.

Protein post-translational modifications

Acetylation by EP300 and CREBBP destabilizes ITPK1, and down-regulates enzymatic activity. Deacetylated by SIRT1. .

Research area

All research areas>Signaling Intermediates>MIPP
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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