Anti-JMJD6 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-JMJD6 Antibody (CSB-PA750768ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Histone arginine demethylase JMJD6 Antibody,JmjC domain-containing protein 6 Antibody,Jumonji domain-containing protein 6 Antibody,Lysyl-hydroxylase JMJD6 Antibody,Peptide-lysine 5-dioxygenase JMJD6 Antibody,Phosphatidylserine receptor Antibody,Protein PTDSR Antibody,JMJD6 Antibody,KIAA0585 Antibody, PTDSR Antibody

More alternative names for the antibody
Apoptotic cell clearance receptor antibody|Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 antibody|Histone arginine demethylase JMJD6 antibody|JmjC domain-containing protein 6 antibody|JMJD 6 antibody|JMJD6 antibody|JMJD6_HUMAN antibody|Jumonji domain containing 6 antibody|Jumonji domain-containing protein 6 antibody|KIAA0585 antibody|Lysyl-hydroxylase JMJD6 antibody|Peptide-lysine 5-dioxygenase JMJD6 antibody|Phosphatidylserine receptor antibody|Protein PTDSR antibody|PSR antibody|PTDSR 1 antibody|PTDSR antibody|PTDSR1 antibody
Anti-JMJD6 antibody (ab134293)
Close sc-32740|sc-48405|sc-28349|sc-11366|sc-28348|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-JMJD6 Antibody

Catalogue No.

CSB-PA750768ESR1HU

Reactivity

Human

Immunogen

Recombinant humanBifunctional arginine demethylase and lysyl-hydroxylase JMJD6 protein (1-320AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

46 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:417355( Chicken), Entrez Gene:508343( Cow), Entrez Gene:23210( Human), Entrez Gene:107817( Mouse), Entrez Gene:100173544( Orangutan), Entrez Gene:360665( Rat), Entrez Gene:266962( Zebrafish), Omim:604914( Human), SwissProt:Q5ZMK5( Chicken), SwissProt:Q58DS6( Cow), SwissProt:Q6NYC1( Human), SwissProt:Q9ERI5( Mouse), SwissProt:Q5R6G2( Orangutan), SwissProt:Q6AYK2( Rat), SwissProt:Q7ZX37( Xenopus laevis), SwissProt:Q6PFM0( Zebrafish), Unigene:514505( Human), Unigene:383423( Mouse), Unigene:19923( Rat), Unigene:86243( Zebrafish)

Protein function

Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at ‘Arg-2’ (H3R2me) and histone H4 at ‘Arg-3’ (H4R3me), thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65. Seems to be necessary for the regulation of macrophage cytokine responses. .

Protein tissue specificity

Highly expressed in the heart, skeletal muscle and kidney. Expressed at moderate or low level in brain, placenta, lung, liver, pancreas, spleen, thymus, prostate, testis and ovary. Up-regulated in many patients with chronic pancreatitis. Expressed in nursing thymic epithelial cells. .

Protein sequence and domain

Belongs to the JMJD6 family. The nuclear localization signal motifs are necessary and sufficient to target it into the nucleus.

Protein cellular localization

Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Mainly found throughout the nucleoplasm outside of regions containing heterochromatic DNA, with some localization in nucleolus. During mitosis, excluded from the nucleus and reappears in the telophase of the cell cycle.

Research area

All research areas>Membrane Receptors>PSR
(View all antibody categories related to Membrane Receptors)

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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