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Rabbit Anti-JMJD6 Antibody (CSB-PA750768ESR1HU)
Supplier: CUSABIO BIOTECH CO.
Histone arginine demethylase JMJD6 Antibody,JmjC domain-containing protein 6 Antibody,Jumonji domain-containing protein 6 Antibody,Lysyl-hydroxylase JMJD6 Antibody,Peptide-lysine 5-dioxygenase JMJD6 Antibody,Phosphatidylserine receptor Antibody,Protein PTDSR Antibody,JMJD6 Antibody,KIAA0585 Antibody, PTDSR AntibodyMore alternative names for the antibody
Apoptotic cell clearance receptor antibody|Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 antibody|Histone arginine demethylase JMJD6 antibody|JmjC domain-containing protein 6 antibody|JMJD 6 antibody|JMJD6 antibody|JMJD6_HUMAN antibody|Jumonji domain containing 6 antibody|Jumonji domain-containing protein 6 antibody|KIAA0585 antibody|Lysyl-hydroxylase JMJD6 antibody|Peptide-lysine 5-dioxygenase JMJD6 antibody|Phosphatidylserine receptor antibody|Protein PTDSR antibody|PSR antibody|PTDSR 1 antibody|PTDSR antibody|PTDSR1 antibody
Anti-JMJD6 antibody (ab134293)
Anti-JMJD6 antibody (ab134293)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant humanBifunctional arginine demethylase and lysyl-hydroxylase JMJD6 protein (1-320AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:417355( Chicken), Entrez Gene:508343( Cow), Entrez Gene:23210( Human), Entrez Gene:107817( Mouse), Entrez Gene:100173544( Orangutan), Entrez Gene:360665( Rat), Entrez Gene:266962( Zebrafish), Omim:604914( Human), SwissProt:Q5ZMK5( Chicken), SwissProt:Q58DS6( Cow), SwissProt:Q6NYC1( Human), SwissProt:Q9ERI5( Mouse), SwissProt:Q5R6G2( Orangutan), SwissProt:Q6AYK2( Rat), SwissProt:Q7ZX37( Xenopus laevis), SwissProt:Q6PFM0( Zebrafish), Unigene:514505( Human), Unigene:383423( Mouse), Unigene:19923( Rat), Unigene:86243( Zebrafish)
|Protein function|| |
Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at ‘Arg-2’ (H3R2me) and histone H4 at ‘Arg-3’ (H4R3me), thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65. Seems to be necessary for the regulation of macrophage cytokine responses. .
|Protein tissue specificity|| |
Highly expressed in the heart, skeletal muscle and kidney. Expressed at moderate or low level in brain, placenta, lung, liver, pancreas, spleen, thymus, prostate, testis and ovary. Up-regulated in many patients with chronic pancreatitis. Expressed in nursing thymic epithelial cells. .
|Protein sequence and domain|| |
Belongs to the JMJD6 family. The nuclear localization signal motifs are necessary and sufficient to target it into the nucleus.
|Protein cellular localization|| |
Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Mainly found throughout the nucleoplasm outside of regions containing heterochromatic DNA, with some localization in nucleolus. During mitosis, excluded from the nucleus and reappears in the telophase of the cell cycle.
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CUSABIO BIOTECH CO.
|Product type|| |
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