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Rabbit Anti-KCNH1 Antibody (CSB-PA012035DSR2HU)
Supplier: CUSABIO BIOTECH CO.
Potassium voltage-gated channel subfamily H member 1 Antibody,Ether-a-go-go potassium channel 1 Antibody,EAG channel 1 Antibody,h-eag Antibody,hEAG1 Antibody,Voltage-gated potassium channel subunit Kv10.1 Antibody,KCNH1 Antibody,EAG Antibody,EAG1 AntibodyMore alternative names for the antibody
EAG antibody|Potassium voltage-gated channel subfamily H member 1 antibody|Voltage gated potassium channel subunit Kv10.1 antibody|Voltage-gated potassium channel subunit Kv10.1 antibody
Anti-KCNH1 antibody (ab194350)
Anti-KCNH1 antibody (ab194350)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Potassium voltage-gated channel subfamily H member 1 protein (840-989AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:281881( Cow), Entrez Gene:3756( Human), Entrez Gene:16510( Mouse), Entrez Gene:65198( Rat), Omim:603305( Human), SwissProt:O18965( Cow), SwissProt:O95259( Human), SwissProt:Q60603( Mouse), SwissProt:Q63472( Rat), Unigene:553187( Human), Unigene:4489( Mouse), Unigene:11071( Rat)
|Protein function|| |
Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel (PubMed:9738473, PubMed:11943152, PubMed:10880439, PubMed:22732247, PubMed:25556795, PubMed:27325704, PubMed:27005320, PubMed:27618660). Channel properties are modulated by subunit assembly (PubMed:11943152). Mediates IK(NI) current in myoblasts (PubMed:9738473). Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (PubMed:23881642). .
|Protein tissue specificity|| |
Highly expressed in brain and in myoblasts at the onset of fusion, but not in other tissues. Detected in HeLa (cervical carcinoma), SH-SY5Y (neuroblastoma) and MCF-7 (epithelial tumor) cells, but not in normal epithelial cells.
|Involvement in disease|| |
Temple-Baraitser syndrome (TMBTS) [MIM:611816]: A developmental disorder characterized by intellectual disability, epilepsy, hypoplasia or aplasia of the thumb and great toe nails, and broadening and/or elongation of the thumbs and halluces, which have a tubular aspect. Some patients show facial dysmorphism. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Zimmermann-Laband syndrome 1 (ZLS1) [MIM:135500]: A disorder characterized by gingival fibromatosis, dysplastic or absent nails, finger abnormalities, hepatosplenomegaly, and abnormalities of the cartilage of the nose and/or ears. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv10.1/KCNH1 sub-subfamily. The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.; The C-terminal region interacts with the cyclic nucleotide-binding domain and contributes to regulate channel gating.; The PAS and PAC domain interact with the cyclic nucleotide-binding domain and contribute to the regulation of channel gating (PubMed:27325704). Calmodulin binding clamps together the PAS and PAC domain with the cyclic nucleotide-binding domain from a neighboring subunit and causes a conformation change that leads to channel closure.; The cyclic nucleotide-binding domain lacks residues that are essential for nucleotide-binding and cannot bind cyclic nucleotides. Instead, residues from the C-terminal domain (the so-called intrinsic ligand) bind in the cavity that would be expected to bind cyclic nucleotides. Interaction with the C-terminal region hinders interaction with CALM and reduces the affinity for CALM.
|Protein post-translational modifications|| |
Channel activity is regulated via tyrosine phosphorylation/dephosphorylation by SRC and PTPN6 (PubMed:24587194). .
|Protein cellular localization|| |
Cell membrane ; Multi-pass membrane protein . Nucleus inner membrane ; Multi-pass membrane protein . Cell projection, dendrite . Cell projection, axon . Cell junction, synapse, presynaptic cell membrane . Perikaryon . Cell junction, synapse, postsynaptic cell membrane, postsynaptic density . Early endosome membrane . Note=Perinuclear KCNH1 is located to NPC-free islands.
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CUSABIO BIOTECH CO.
|Product type|| |
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