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Rabbit Anti-KCNN4 Antibody (CSB-PA012086ESR2HU)
Supplier: CUSABIO BIOTECH CO.
SK4 Antibody,SKCa 4 Antibody,SKCa4 Antibody,IKCa1 Antibody, IK1 Antibody,KCa3.1 Antibody,KCa4 Antibody,Putative Gardos channel Antibody,KCNN4 Antibody,IK1 Antibody, IKCA1 Antibody, KCA4 Antibody, SK4 AntibodyMore alternative names for the antibody
hIKCa1 antibody|hKCa4 antibody|hSK4 antibody|IK1 antibody|IKCa1 antibody|Intermediate conductance calcium activated potassium channel protein 4 antibody|Intermediate conductance calcium-activated potassium channel protein 4 antibody|KCa3.1 antibody|KCa4 antibody|KCNN 4 antibody|Kcnn4 antibody|KCNN4_HUMAN antibody|Potassium intermediate/small conductance calcium activated channel, subfamily N, member 4 antibody|Putative Gardos channel antibody|SK4 antibody|SKCa 4 antibody|SKCa4 antibody
Anti-KCNN4 antibody (ab215990)
Anti-KCNN4 antibody (ab215990)
Recommended applications: ELISA, WB, IHC
Recommended dilution: Recommended dilution:WB:1:500-5000,IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Intermediate conductance calcium-activated potassium channel protein 4 protein (288-427AA)
ELISA, WB, IHC
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
|Database links|| |
Entrez Gene:3783( Human), Entrez Gene:16534( Mouse), Entrez Gene:65206( Rat), Omim:602754( Human), SwissProt:O15554( Human), SwissProt:O89109( Mouse), SwissProt:Q9QYW1( Rat), Unigene:10082( Human), Unigene:9911( Mouse), Unigene:44212( Rat)
|Protein function|| |
Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed:26148990). Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin (PubMed:17157250, PubMed:18796614). .
|Protein tissue specificity|| |
Widely expressed in non-excitable tissues.
|Involvement in disease|| |
Dehydrated hereditary stomatocytosis 2 (DHS2) [MIM:616689]: An autosomal dominant hemolytic anemia characterized by primary erythrocyte dehydration. Erythrocytes exhibit decreased total cation and potassium content that are not accompanied by a proportional net gain of sodium and water. Affected individuals typically manifest mild to moderate compensated hemolytic anemia, with an increased erythrocyte mean corpuscular hemoglobin concentration and a decreased osmotic fragility, both of which reflect cellular dehydration. Their red cells exhibit a panel of various shape abnormalities such as elliptocytes, hemighosts, schizocytes, and very rare stomatocytic cells. Complications such as splenomegaly and cholelithiasis, resulting from increased red cell trapping in the spleen and elevated bilirubin levels, respectively, may occur. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the potassium channel KCNN family. KCa3.1/KCNN4 subfamily.
|Protein post-translational modifications|| |
Phosphorylation at His-358 by NDKB activates the channel, and conversely it’s dephosphorylation by PHPT1 inhibits the channel. .
|Protein cellular localization|| |
Cell membrane ; Multi-pass membrane protein .
CUSABIO BIOTECH CO.
|Product type|| |
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