Anti-KCNN4 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-KCNN4 Antibody (CSB-PA012086ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

SK4 Antibody,SKCa 4 Antibody,SKCa4 Antibody,IKCa1 Antibody, IK1 Antibody,KCa3.1 Antibody,KCa4 Antibody,Putative Gardos channel Antibody,KCNN4 Antibody,IK1 Antibody, IKCA1 Antibody, KCA4 Antibody, SK4 Antibody

More alternative names for the antibody
hIKCa1 antibody|hKCa4 antibody|hSK4 antibody|IK1 antibody|IKCa1 antibody|Intermediate conductance calcium activated potassium channel protein 4 antibody|Intermediate conductance calcium-activated potassium channel protein 4 antibody|KCa3.1 antibody|KCa4 antibody|KCNN 4 antibody|Kcnn4 antibody|KCNN4_HUMAN antibody|Potassium intermediate/small conductance calcium activated channel, subfamily N, member 4 antibody|Putative Gardos channel antibody|SK4 antibody|SKCa 4 antibody|SKCa4 antibody
Anti-KCNN4 antibody (ab215990)
Close sc-27082|sc-365265|sc-27081|sc-27080|sc-32949|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-KCNN4 Antibody

Catalogue No.

CSB-PA012086ESR1HU

Reactivity

Human

Immunogen

Recombinant human Intermediate conductance calcium-activated potassium channel protein 4 protein (288-427AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

47 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:3783( Human), Entrez Gene:16534( Mouse), Entrez Gene:65206( Rat), Omim:602754( Human), SwissProt:O15554( Human), SwissProt:O89109( Mouse), SwissProt:Q9QYW1( Rat), Unigene:10082( Human), Unigene:9911( Mouse), Unigene:44212( Rat)

Protein function

Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed:26148990). Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin (PubMed:17157250, PubMed:18796614). .

Protein tissue specificity

Widely expressed in non-excitable tissues.

Involvement in disease

Dehydrated hereditary stomatocytosis 2 (DHS2) [MIM:616689]: An autosomal dominant hemolytic anemia characterized by primary erythrocyte dehydration. Erythrocytes exhibit decreased total cation and potassium content that are not accompanied by a proportional net gain of sodium and water. Affected individuals typically manifest mild to moderate compensated hemolytic anemia, with an increased erythrocyte mean corpuscular hemoglobin concentration and a decreased osmotic fragility, both of which reflect cellular dehydration. Their red cells exhibit a panel of various shape abnormalities such as elliptocytes, hemighosts, schizocytes, and very rare stomatocytic cells. Complications such as splenomegaly and cholelithiasis, resulting from increased red cell trapping in the spleen and elevated bilirubin levels, respectively, may occur. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the potassium channel KCNN family. KCa3.1/KCNN4 subfamily.

Protein post-translational modifications

Phosphorylation at His-358 by NDKB activates the channel, and conversely it’s dephosphorylation by PHPT1 inhibits the channel. .

Protein cellular localization

Cell membrane ; Multi-pass membrane protein .

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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