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Rabbit Anti-KHDRBS3 Antibody (CSB-PA012156ESR2HU)
Supplier: CUSABIO BIOTECH CO.
KH domain-containing Antibody,RNA-binding Antibody,signal transduction-associated protein 3 Antibody,RNA-binding protein T-Star Antibody,Sam68-like mammalian protein 2 Antibody,SLM-2 Antibody,Sam68-like phosphotyrosine protein Antibody,KHDRBS3 Antibody,SALP Antibody,SLM2 AntibodyMore alternative names for the antibody
Etle antibody|etoile antibody|KH domain containing RNA binding signal transduction associated 3 antibody|KH domain containing RNA binding signal transduction associated protein 3 antibody|KH domain-containing antibody|KHDR3_HUMAN antibody|Khdrbs3 antibody|RNA binding protein T Star antibody|RNA-binding antibody|RNA-binding protein T-Star antibody|SALP antibody|Sam68 like mammalian protein 2 antibody|Sam68 like phosphotyrosine protein antibody|Sam68 like phosphotyrosine protein T STAR antibody|Sam68-like mammalian protein 2 antibody|Sam68-like phosphotyrosine protein antibody|signal transduction-associated protein 3 antibody|SLM 2 antibody|SLM-2 antibody|SLM2 antibody|T STAR antibody|TSTAR antibody
Anti-KHDRBS3 antibody (ab68515)
Anti-KHDRBS3 antibody (ab68515)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human KH domain-containing, RNA-binding, signal transduction-associated protein 3 protein (177-346AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Protein function|| |
RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds preferentially to the 5′-[AU]UAAA-3′ motif in vitro. Binds optimally to RNA containing 5′-[AU]UAA-3′ as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). RNA-binding abilities are down-regulated by tyrosine kinase PTK6 (PubMed:10564820, PubMed:19561594, PubMed:26758068). Involved in splice site selection of vascular endothelial growth factor (PubMed:15901763). In vitro regulates CD44 alternative splicing by direct binding to purine-rich exonic enhancer (By similarity). Can regulate alternative splicing of neurexins NRXN1-3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners such as neuroligins and LRRTM family members (PubMed:26758068). Targeted, cell-type specific splicing regulation of NRXN1 at AS4 is involved in neuronal glutamatergic synapse function and plasticity (By similarity). May regulate expression of KHDRBS2/SLIM-1 in defined brain neuron populations by modifying its alternative splicing (By similarity). Can bind FABP9 mRNA (By similarity). May play a role as a negative regulator of cell growth. Inhibits cell proliferation. .; (Microbial infection) Involved in post-transcriptional regulation of HIV-1 gene expression. .
|Protein tissue specificity|| |
Ubiquitous with higher expression in testis, skeletal muscle and brain. Expressed in the kidney only in podocytes, the glomerular epithelial cells of the kidney. Strongly expressed after meiosis. .
|Protein sequence and domain|| |
Belongs to the KHDRBS family. The proline-rich site binds the SH3 domain of the p85 subunit of PI3-kinase.
|Protein post-translational modifications|| |
Phosphorylated on tyrosine residues. Isoform 1 C-terminal region is tyrosine-rich, but isoform 2 lacking this C-terminal region is also tyrosine-phosphorylated. .
|Protein cellular localization|| |
Nucleus . Note=Localized in a compartment adjacent to the nucleolus, but distinct from the peri-nucleolar one.
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CUSABIO BIOTECH CO.
|Product type|| |
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