Anti-KHDRBS3 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-KHDRBS3 Antibody (CSB-PA012156ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

KH domain-containing Antibody,RNA-binding Antibody,signal transduction-associated protein 3 Antibody,RNA-binding protein T-Star Antibody,Sam68-like mammalian protein 2 Antibody,SLM-2 Antibody,Sam68-like phosphotyrosine protein Antibody,KHDRBS3 Antibody,SALP Antibody,SLM2 Antibody

More alternative names for the antibody
Etle antibody|etoile antibody|KH domain containing RNA binding signal transduction associated 3 antibody|KH domain containing RNA binding signal transduction associated protein 3 antibody|KH domain-containing antibody|KHDR3_HUMAN antibody|Khdrbs3 antibody|RNA binding protein T Star antibody|RNA-binding antibody|RNA-binding protein T-Star antibody|SALP antibody|Sam68 like mammalian protein 2 antibody|Sam68 like phosphotyrosine protein antibody|Sam68 like phosphotyrosine protein T STAR antibody|Sam68-like mammalian protein 2 antibody|Sam68-like phosphotyrosine protein antibody|signal transduction-associated protein 3 antibody|SLM 2 antibody|SLM-2 antibody|SLM2 antibody|T STAR antibody|TSTAR antibody
Anti-KHDRBS3 antibody (ab68515)
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Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-KHDRBS3 Antibody

Catalogue No.

CSB-PA012156ESR2HU

Reactivity

Human

Immunogen

Recombinant human KH domain-containing, RNA-binding, signal transduction-associated protein 3 protein (177-346AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

38 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:10656( Human), Entrez Gene:64015( Rat), Omim:610421( Human), SwissProt:O75525( Human), SwissProt:Q9JLP1( Rat), Unigene:444558( Human), Unigene:54682( Rat)

Protein function

RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds preferentially to the 5′-[AU]UAAA-3′ motif in vitro. Binds optimally to RNA containing 5′-[AU]UAA-3′ as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). RNA-binding abilities are down-regulated by tyrosine kinase PTK6 (PubMed:10564820, PubMed:19561594, PubMed:26758068). Involved in splice site selection of vascular endothelial growth factor (PubMed:15901763). In vitro regulates CD44 alternative splicing by direct binding to purine-rich exonic enhancer (By similarity). Can regulate alternative splicing of neurexins NRXN1-3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners such as neuroligins and LRRTM family members (PubMed:26758068). Targeted, cell-type specific splicing regulation of NRXN1 at AS4 is involved in neuronal glutamatergic synapse function and plasticity (By similarity). May regulate expression of KHDRBS2/SLIM-1 in defined brain neuron populations by modifying its alternative splicing (By similarity). Can bind FABP9 mRNA (By similarity). May play a role as a negative regulator of cell growth. Inhibits cell proliferation. .; (Microbial infection) Involved in post-transcriptional regulation of HIV-1 gene expression. .

Protein tissue specificity

Ubiquitous with higher expression in testis, skeletal muscle and brain. Expressed in the kidney only in podocytes, the glomerular epithelial cells of the kidney. Strongly expressed after meiosis. .

Protein sequence and domain

Belongs to the KHDRBS family. The proline-rich site binds the SH3 domain of the p85 subunit of PI3-kinase.

Protein post-translational modifications

Phosphorylated on tyrosine residues. Isoform 1 C-terminal region is tyrosine-rich, but isoform 2 lacking this C-terminal region is also tyrosine-phosphorylated. .

Protein cellular localization

Nucleus . Note=Localized in a compartment adjacent to the nucleolus, but distinct from the peri-nucleolar one.

Research area

All research areas>Signaling Intermediates>SLM
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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