Anti-KIF2C Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-KIF2C Antibody (CSB-PA860347ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Kinesin-like protein 6 Antibody,Mitotic centromere-associated kinesin Antibody, MCAK Antibody,KIF2C Antibody,KNSL6 Antibody

More alternative names for the antibody
4930402F02Rik antibody|CT139 antibody|ESTM5 antibody|KIF 2C antibody|kif2c antibody|KIF2C_HUMAN antibody|Kinesein Family Member 2C antibody|Kinesin family member 2C antibody|kinesin like 6 (mitotic centromere associated kinesin) antibody|Kinesin like 6 antibody|Kinesin like protein 6 antibody|Kinesin like protein KIF2C antibody|Kinesin-like protein 6 antibody|Kinesin-like protein KIF2C antibody|KNS L6 antibody|KNSL 6 antibody|KNSL6 antibody|MCAK antibody|MGC11883 antibody|Mitotic centromere associated kinesin antibody|Mitotic centromere-associated kinesin antibody|OTTHUMP00000010066 antibody|X83316 antibody
Anti-MCAK antibody [EPR14838] (ab187652)
Close sc-81305|sc-30277|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-KIF2C Antibody

Catalogue No.

CSB-PA860347ESR1HU

Reactivity

Human

Immunogen

Recombinant humanKinesin-like protein KIF2C protein (1-190AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

81 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:11004( Human), Omim:604538( Human), SwissProt:Q99661( Human), Unigene:720061( Human)

Protein function

In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (PubMed:21820309). Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis (PubMed:19060894). Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment (PubMed:23891108). .

Protein tissue specificity

Expressed at high levels in thymus and testis, at low levels in small intestine, the mucosal lining of colon, and placenta, and at very low levels in spleen and ovary; expression is not detected in prostate, peripheral blood Leukocytes, heart, brain, lung, liver, skeletal muscle, kidney or pancreas. Isoform 2 is testis-specific. .

Protein sequence and domain

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily. The microtubule tip localization signal (MtLS) motif; mediates interaction with MAPRE1 and targeting to the growing microtubule plus ends.

Protein post-translational modifications

Phosphorylation by AURKB, regulates association with centromeres and kinetochores and the microtubule depolymerization activity. .; Ubiquitinated. .

Protein cellular localization

Cytoplasm, cytoskeleton . Nucleus . Chromosome, centromere . Chromosome, centromere, kinetochore . Note=Associates with the microtubule network at the growing distal tip (the plus-end) of microtubules, probably through interaction with MTUS2/TIP150 and MAPRE1 (By similarity). Association with microtubule plus ends is also mediated by interaction with KIF18B. Centromeric localization requires the presence of BUB1 and SGO2. .

Research area

All research areas>Structural Proteins>KIF
(View all antibody categories related to Structural Proteins)

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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