Anti-KITLG Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-KITLG Antibody (CSB-PA012376ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Mast cell growth factor Antibody,MGF Antibody,Stem cell factor Antibody,SCF Antibody,c-Kit ligand Antibody,sKITLG Antibody,KITLG Antibody,MGF Antibody, SCF Antibody

More alternative names for the antibody
C kit ligand antibody|C-kit ligand antibody|Ckit ligand antibody|DCUA antibody|DFNA69 antibody|DKFZp686F2250 antibody|familial progressive hyperpigmentation 2 antibody|FPH2 antibody|FPHH antibody|KIT ligand antibody|Kitl antibody|KITLG antibody|KL 1 antibody|KL1 antibody|Mast cell growth factor antibody|MGF antibody|MGF stem cell factor antibody|SCF antibody|SCF_HUMAN antibody|SF antibody|SHEP7 antibody|sKITLG antibody|Soluble KIT ligand antibody|Steel factor antibody|steel, mouse, homolog of antibody|Stem cell factor antibody|Stem cell factor precursor antibody
Anti-SCF antibody (ab64677)
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Recommended applications: ELISA, WB

Recommended dilution: Recommended dilution:WB:1:500-2000

Recommended protocols: check protocols

Name

Anti-KITLG Antibody

Catalogue No.

CSB-PA012376ESR2HU

Reactivity

Human

Immunogen

Recombinant human Kit ligand protein (26-214AA)

Host

Rabbit

Applications

ELISA, WB

Recommended dilution

Recommended dilution:WB:1:500-2000

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

30 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:4254( Human), Entrez Gene:17311( Mouse), Entrez Gene:60427( Rat), Omim:184745( Human), SwissProt:P21583( Human), SwissProt:P20826( Mouse), SwissProt:P21581( Rat), Unigene:1048( Human), Unigene:661108( Human), Unigene:45124( Mouse), Unigene:44216( Rat)

Protein function

Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.

Involvement in disease

Hyperpigmentation with or without hypopigmentation, familial progressive (FPHH) [MIM:145250]: A disorder characterized by hyperpigmented patches in the skin, present in early infancy and increasing in size and number with age. Hyperpigmentation has variable intensity, and sometimes is associated with cafe-au-lait macules and larger hypopigmented ash-leaf macules. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Deafness, congenital, unilateral or asymmetric (DCUA) [MIM:616697]: An autosomal dominant form of non-syndromic, sensorineural deafness characterized by inability to hear affecting one ear. Some patients suffers from asymmetric, bilateral hearing loss. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the SCF family.

Protein post-translational modifications

A soluble form (sKITLG) is produced by proteolytic processing of isoform 1 in the extracellular domain. .; Found in two differentially glycosylated forms, LMW-SCF and HMW-SCF. LMW-SCF is fully N-glycosylated at Asn-145, partially N-glycosylated at Asn-90, O-glycosylated at Ser-167, Thr-168 and Thr-180, and not glycosylated at Asn-97 or Asn-118. HMW-SCF is N-glycosylated at Asn-118, Asn-90 and Asn-145, O-glycosylated at Ser-167, Thr-168 and Thr-180, and not glycosylated at Asn-97. .; A soluble form exists as a cleavage product of the extracellular domain. .

Protein cellular localization

Isoform 1: Cell membrane; Single-pass type I membrane protein.; Isoform 2: Cytoplasm . Cytoplasm, cytoskeleton . Cell membrane ; Single-pass type I membrane protein . Cell projection, lamellipodium . Cell projection, filopodium .; Soluble KIT ligand: Secreted.

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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