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Rabbit Anti-KLF15 Antibody (CSB-PA883433ESR2HU)
Supplier: CUSABIO BIOTECH CO.
Krueppel-like factor 15 Antibody,Kidney-enriched krueppel-like factor Antibody,KLF15 Antibody,KKLF AntibodyMore alternative names for the antibody
Kidney enriched Kruppel like factor antibody|Kidney-enriched krueppel-like factor antibody|KKLF antibody|KKLF protein antibody|KLF 15 antibody|KLF15 antibody|KLF15_HUMAN antibody|Krueppel-like factor 15 antibody|Kruppel like factor 15 antibody
Anti-KLF15 antibody (ab2647)
Anti-KLF15 antibody (ab2647)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Krueppel-like factor 15 protein (1-260AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:28999( Human), Entrez Gene:66277( Mouse), Entrez Gene:85497( Rat), GenBank:NP_054798.1( Human), Omim:606465( Human), SwissProt:Q9UIH9( Human), SwissProt:Q9EPW2( Mouse), Unigene:272215( Human), Unigene:41389( Mouse), Unigene:22556( Rat)
|Protein function|| |
Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By similarity). Is a repressor of CTGF expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity). Involved in podocyte differentiation (By similarity). Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation. .
|Protein tissue specificity|| |
Highly expressed in liver, skeletal muscle, and kidney. Expressed in cardiomyocytes. Expression is highly reduced in cardiac tissue of patients with non-ischemic cardiomyopathy and aortic aneurysm, and in glomerular disease. Not expressed in bone marrow or lymphoid tissues. .
|Involvement in disease|| |
Note=KLF15 deficiency results in loss of rhythmic QT variation and abnormal heart repolarization (PubMed:22367544). It may play a role in susceptibility to ventricular arrhythmias (PubMed:22367544), and development of pathological cardiac hypertrophy leading to heart failure (PubMed:20375365). .
|Protein sequence and domain|| |
Belongs to the Sp1 C2H2-type zinc-finger protein family.
|Protein cellular localization|| |
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|Product type|| |
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